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Author:

Lehmann, Andreas

Title:

Molecular Design in Chemical and Biological Systems

Graduate Program:

Chemical Engineering

Keywords:

quantum chemistry
molecular design
protein design
protein engineering

File:

Download andreas_thesis.pdf

Committee Members:

Costas D Maranas, Committee Chair/Co-Chair
Margaret K Duda, Committee Member
Kristen Ann Fichthorn, Committee Member
Barbara Jane Garrison, Committee Member

Author:

Khoury, George Adeeb

Title:

COMPUTATIONAL DESIGN TO SWITCH PROTEIN COFACTOR SPECIFICITY AND CREATE ENZYMATIC ACTIVITY

Graduate Program:

Chemical Engineering

Keywords:

evolution
protein design
protein engineering
computation
mutagenesis
cofactor

File:

Download thesisdraftfinal.pdf

Committee Members:

Costas D Maranas, Thesis Advisor/Co-Advisor
Costas D Maranas, Thesis Advisor/Co-Advisor

Author:

Moore, Gregory Lee

Title:

Modeling and Optimization in Directed Evolution Protocols and Protein Engineering

Graduate Program:

Chemical Engineering

Keywords:

directed evolution
protein engineering
optimization

File:

Download thesis.pdf

Committee Members:

Costas D Maranas, Committee Chair/Co-Chair
Ali Borhan, Committee Member
Patrick Cirino, Committee Member
Stephen James Benkovic, Committee Member
Andrew Zydney, Committee Member

Author:

Li, Hui

Title:

PROTEIN ENGINEERING OF STRUCTURALLY HOMOLOGOUS PROTEINS

Graduate Program:

Integrative Biosciences

Keywords:

protein evolution
protein engineering
purine biosynthetic pathway
domain swapping
(β/α)8 barrel protein

File:

Download ThesisMaster.pdf

Committee Members:

Stephen James Benkovic, Committee Chair/Co-Chair
Costas D Maranas, Committee Member
Squire J Booker, Committee Member
Ming Tien, Committee Member

Author:

Schweiker, Katrina Lynn

Title:

Computational Design and Experimental Characterization of Proteins with Increased Stability and Solubility

Graduate Program:

Integrative Biosciences

Keywords:

protein stability
protein engineering
computational design
protein folding

File:

Download KLSfinal.pdf

Committee Members:

George Makhatadze, Dissertation Advisor/Co-Advisor
George I Makhatadze, Committee Chair/Co-Chair
Judith S Bond, Committee Member
Thomas E Spratt, Committee Member
Philip C. Bevilacqua, Committee Member

Author:

Saraf, Manish Chandra

Title:

DEVELOPMENT OF COMPUTATIONAL TOOLS FOR THE DESIGN AND OPTIMIZATION OF COMBINATORIAL PROTEIN LIBRARIES

Graduate Program:

Chemical Engineering

Keywords:

protein engineering
directed evolution
bioinformatics
protein library design
optimization

File:

Download Thesis.pdf

Committee Members:

Michael Pishko, Committee Member
Patrick Cirino, Committee Member
Stephen James Benkovic, Committee Member
Andrew Zydney, Committee Member
Costas D Maranas, Committee Chair/Co-Chair