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Author:

Szakal, Andrea

Title:

THE HEPATITIS DELTA VIRUS (HDV) RIBOZYME AS A MODEL FOR RNA CATALYSIS AND FOLDING

Graduate Program:

Chemistry

Keywords:

RNA folding
RNA catalysis

File:

Download Szakal_Doctoral_ThesisMaster_041508.pdf

Committee Members:

Sharon Hammes Schiffer, Committee Member
Christine Dolan Keating, Committee Member
Craig Eugene Cameron, Committee Member
Philip C. Bevilacqua, Committee Chair/Co-Chair

Author:

Harki, Daniel Allen

Title:

Chemical Synthesis of Base-Modified Ribonucleosides as Novel Antiviral Agents

Graduate Program:

Chemistry

Keywords:

universal base
coxsackievirus
poliovirus
lethal mutagenesis
RNA virus
RNA-dependent RNA polymerase
nucleotides
nucleosides
ribonucleosides
antiviral agents
nucleoside synthesis

File:

Download Harki_PhD_Thesis.pdf

Committee Members:

Blake Peterson, Committee Chair/Co-Chair
Craig Eugene Cameron, Committee Member
Ken S Feldman, Committee Member
Joseph M Bollinger Jr., Committee Member

Author:

Edathil, Jocelyn P

Title:

DESIGN, SYNTHESIS, ANTIVIRAL EVALUATION AND METABOLISM OF NUCLEOSIDE ANALOGS

Graduate Program:

Chemistry

Keywords:

nucleotides
universal base
poliovirus
lethal mutagenesis
nucleoside synthesis
RNA virus
nucleosides
RNA-dependent RNA polymerase
carbohydrate synthesis
nucleoside phosphorylation

File:

Download EdathilThesisFinal.pdf

Committee Members:

Blake R Peterson, Committee Chair/Co-Chair
Gong Chen, Committee Member
Craig Eugene Cameron, Committee Member
Anthony Edward Pegg, Committee Member

Author:

Toroney, Rebecca

Title:

Investigating Roles of Unconventional RNA Primary, Secondary, and Tertiary Motifs in Regulation of the Protein Kinase PKR

Graduate Program:

Chemistry

Keywords:

Hepatitis C Virus
RNA-protein interactions
IRES
PKR
innate immunity
triphosphate

File:

Download Toroney_R_Thesis.pdf

Committee Members:

Philip C. Bevilacqua, Dissertation Advisor/Co-Advisor
Philip C. Bevilacqua, Committee Chair/Co-Chair
Nicholas Winograd, Committee Member
Scott A Showalter, Committee Member
Craig Eugene Cameron, Committee Member

Author:

Zaccardi, Margot Joan

Title:

mechanistic analysis of the tryptophan biosynthetic enzyme indole-3-glycerol phosphate synthase

Graduate Program:

Chemistry

Keywords:

indole-3-glycerol phosphate synthase
enzyme kinetics
mechanism of IGPS
thermophilic enzymes
enzyme engineering

File:

Download Zaccardi_Final.pdf

Committee Members:

David D Boehr, Dissertation Advisor/Co-Advisor
Scott A Showalter, Committee Chair/Co-Chair
Philip C. Bevilacqua, Committee Member
Craig Eugene Cameron, Special Member

Author:

Rembert, Kelvin B

Title:

Ion Specificity at the Polypeptide Backbone: molecular Mechanisms of the Hofmeister Effect

Graduate Program:

Chemistry

Keywords:

Hofmeister Series
Ions
Polymers
Water
NMR
LCST
FTIR

File:

Download Dissertation_102714.pdf

Committee Members:

Paul S Cremer, Dissertation Advisor/Co-Advisor
Scott A Showalter, Committee Chair/Co-Chair
William George Noid, Committee Member
Craig Eugene Cameron, Special Member

Author:

Chan, Yan Mei

Title:

Functional Regulation and Protein Structural Dynamics of Poliovirus 3c Protease

Graduate Program:

Chemistry

Keywords:

Viruses
Poliovirus
Structural Dynamics
Functional Regulation
3C Protease
Protein NMR

File:

Download YMC_Dissertation20150708.pdf

Committee Members:

David D Boehr, Dissertation Advisor/Co-Advisor
David D Boehr, Committee Chair/Co-Chair
Squire J Booker, Committee Member
Emmanuel Hatzakis, Committee Member
Craig Eugene Cameron, Committee Member

Author:

Liu, Xinran

Title:

Investigation of the nucleotide selection mechanism of poliovirus Rna-dependent Rna polymerase

Graduate Program:

Chemistry

Keywords:

Poliovirus
nucleotide
selection
fidelity
polymerase

File:

Download Xinran_Liu_20151130_last_edit.pdf

Committee Members:

David D Boehr, Dissertation Advisor/Co-Advisor
Craig Eugene Cameron, Committee Member
Scott A Showalter, Committee Member
John H Golbeck, Committee Member

Author:

Hull, Chelsea Michelle

Title:

Mechanistic Investigation Of Activation Of The Innate Immune Sensor Pkr By Various Levels And Types Of Rna Structure

Graduate Program:

Chemistry

Keywords:

PKR
RNA
bacterial RNA
riboswitch
ribozyme
innate immunity

File:

Download Hull_CM_2016.pdf

Committee Members:

Philip C. Bevilacqua, Dissertation Advisor/Co-Advisor
Scott A Showalter, Committee Member
Christine Dolan Keating, Committee Member
Craig Eugene Cameron, Committee Member

Author:

Acevedo, Roderico

Title:

Investigation of protein-RNA interactions of the TAR-RNA-binding protein (TRBP)

Graduate Program:

Chemistry

Keywords:

Biophysics
Binding
TRBP
miRNA
RNAi

File:

Download Dissertation_RA.pdf

Committee Members:

Scott A Showalter, Dissertation Advisor/Co-Advisor
Philip C. Bevilacqua, Committee Member
Craig Eugene Cameron, Committee Member
Amie Kathleen Boal, Committee Member
Ken S Feldman, Special Member