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Author:

Zaccardi, Margot Joan

Title:

mechanistic analysis of the tryptophan biosynthetic enzyme indole-3-glycerol phosphate synthase

Graduate Program:

Chemistry

Keywords:

indole-3-glycerol phosphate synthase
enzyme kinetics
mechanism of IGPS
thermophilic enzymes
enzyme engineering

File:

Download Zaccardi_Final.pdf

Committee Members:

David D Boehr, Dissertation Advisor/Co-Advisor
Scott A Showalter, Committee Chair/Co-Chair
Philip C. Bevilacqua, Committee Member
Craig Eugene Cameron, Special Member

Author:

Persichetti, Joseph

Title:

Understanding the Role of Multiple Pathways in Enzyme Catalysis with a Hierarchical Markov State Model

Graduate Program:

Chemistry (PHD)

Keywords:

molecular dynamics
markov state model
QM/MM
enzyme kinetics
alanine dipeptide
dihydrofolate reductase
computational
free-energy simulations
finite-temperature string method

File:

Download Joseph_Persichetti_PhD_Thesis_FinalSubmission.pdf

Committee Members:

Lasse Jensen, Major Field Member
Howard Salis, Outside Unit & Field Member
Edward O'Brien, Chair & Dissertation Advisor
Squire Booker, Major Field Member
Philip Bevilacqua, Program Head/Chair

Author:

Rasicci, Dave

Title:

Cardiac Myosin Dysfunction in Genetic Cardiomyopathies and Ischemic Heart Failure

Graduate Program:

Anatomy (PHD)

Keywords:

myosin
motility
enzyme kinetics
cardiomyopathy
interacting heads motif
heart failure

File:

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Committee Members:

William Hancock, Major Field Member
Scot Kimball, Major Field Member
Christopher Yengo, Chair & Dissertation Advisor
Lisa Shantz, Major Field Member
Patricia Mclaughlin, Program Head/Chair
Patricia Mclaughlin, Outside Field Member
Edward Lankford, Outside Unit Member

Author:

Zaniewski, Taylor

Title:

Chemomechanical Characterization of the Superprocessive Kinesin-3 KIF1A

Graduate Program:

Chemistry (PHD)

Keywords:

kinesin
enzyme kinetics
single molecule
biochemistry
biophysics

File:

Download Zaniewski_Dissertation_2022Aug29.pdf

Committee Members:

Paul Cremer, Major Field Member
William Hancock, Co-Chair & Dissertation Advisor
Melissa Rolls, Outside Unit & Field Member
Tae-Hee Lee, Major Field Member
Christine Keating, Co-Chair of Committee
Philip Bevilacqua, Program Head/Chair