Search

Author:

Bauerle, Matthew Richard

Title:

Mechanistic Analysis of the Radical SAM Methylases RlmN and Cfr

Graduate Program:

Chemistry

Keywords:

Radical SAM enzyme
Mechanistic Enzymology
X-ray Crystallography
RlmN and Cfr
Mass Spectrometry
Electron Paramagnetic Resonance (EPR) spectroscopy
Enzyme Kinetics
Rapid Chemical Quench
pH-rate profile
Deuterium Exchange
Directed Evolution
Methylation
Thiyl Radical
Cysteine
Iron-Sulfur Cluster
S-adenosylmethionine
5'-deoxyadenosine
S-adenosylhomocysteine
Radical SAM methylase

File:

Download Bauerle_Thesis_Final.pdf

Committee Members:

Dr. Squire J. Booker, Dissertation Advisor/Co-Advisor
Dr. Squire J. Booker, Committee Chair/Co-Chair
Dr. Amie K. Boal, Committee Member
Dr. J. Martin Bollinger, Committee Member
Dr. William Hancock, Outside Member
Dr. Carsten Krebs, Committee Member