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Author:

Yu, Tian

Title:

Integrative analyses of hippo pathway Mutations in human cancer genome

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

mutation
cancer genome
Hippo Pathway
signal transduction
tumor
mutation correlation

File:

Download Tian_Yus_dissertation_Dec_final.pdf

Committee Members:

Zhi Chun Lai, Dissertation Advisor/Co-Advisor
Zhi Chun Lai, Committee Chair/Co-Chair
Francisco Javier Diaz, Committee Member
Graham Hugh Thomas, Committee Member
Robert Paulson, Special Member

Author:

Ren, Zhen

Title:

Homeostatic control of glutamate receptor expression by GABAergic deficits and ketamine

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Major depressive disorder (MDD)
ketamine
glutamate receptors
GABAA receptors
homeostatic adaptation

File:

Download 1-Thesis__Zhen_Ren_final.pdf

Committee Members:

Bernhard Luscher, Dissertation Advisor/Co-Advisor
Bernhard Luscher, Committee Chair/Co-Chair
Melissa Rolls, Committee Member
Douglas Cavener, Committee Member
Timothy J Jegla, Committee Member
Pamela Hankey Giblin, Committee Member

Author:

Byrska-bishop, Marta Barbara

Title:

Unraveling the mechanism of GATA1s-mediated blood disorders using functional genomics in pluripotent stem cells

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

blood disorders
hematopoiesis
GATA1 transcription factor
transcriptome analysis
induced pluripotent stem cells

File:

Download ByrskaBishop_Dissertation_060215.pdf

Committee Members:

Ross Cameron Hardison, Dissertation Advisor/Co-Advisor
Ross Cameron Hardison, Committee Chair/Co-Chair
Santhosh Girirajan, Committee Member
Qunhua Li, Committee Member
Marylyn Deriggi Ritchie, Committee Member
Melissa Rolls, Committee Member

Author:

Yang, Jie

Title:

programming of CCR10+ skin-homing innate lymphocytes in fetal thymus and adult skin-draining lymph nodes for establishment of skin immune system

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

innate lymphoid cells
skin-homing
CCR10
fetal thymic programming

File:

Download Jie_Yang_Dissertation-Version_3.compressed.pdf

Committee Members:

Na Xiong, Dissertation Advisor/Co-Advisor
Margherita Teresa Anna Cantorna, Committee Member
Pamela Hankey Giblin, Committee Member
Girish Soorappa Kirimanjeswara, Committee Member
Yanming Wang, Committee Member

Author:

Jackson, Walter

Title:

The Role of Megakaryocytes in Breast Cancer Metastasis to Bone.

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Breast Cancer
Megakaryocytes
Bone metastasis
Thrombopoietin
Stromal derived factor-1
Platelets
Extramedullary Hematopoiesis

File:

Download Walter_Jackson_Final_Thesis.pdf

Committee Members:

Andrea Marie Mastro, Dissertation Advisor/Co-Advisor
Andrea Marie Mastro, Committee Chair/Co-Chair
Pamela Hankey Giblin, Committee Member
Mary J Kennett, Committee Member
Robert Paulson, Committee Member
Henry Joseph Donahue, Special Member
Melissa Rolls, Committee Member

Author:

Schink, Alisa Elizabeth

Title:

Genetic Analysis of Smoking-based Phenotypes Using Polygenic Risk Score Methodology through Identification of Risk Alleles within the Direct and Indirect Striatal Pathways

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Polygenic Risk Score
Direct Indirect striatal pathway
Basal Ganglia
Addiction
Smoking

File:

Download 07282015_Reward_learning_genetic_risk_score.pdf

Committee Members:

David John Vandenbergh, Thesis Advisor/Co-Advisor

Author:

Li, Xiaofan

Title:

Evolution origins and Pip2 modulation of voltage-gated K+ channels

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

potassium channel
ion channel
evolution
phosphoinositide
PIP2
excitability
ctenophore
nematostella

File:

Download Xiaofan_Li_Dissertation.pdf

Committee Members:

Timothy J Jegla, Dissertation Advisor/Co-Advisor
Timothy J Jegla, Committee Chair/Co-Chair
Bernhard Luscher, Committee Member
David John Vandenbergh, Committee Member
Melissa Rolls, Committee Member

Author:

Chen, Xiangyun

Title:

Novel Self-assemble nanoparticles to inhibit cancer growth -effects on ER stress, autophagy, and multidrug resistance by a small molecule

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Nanomedicine
Multi-drug resistance
cancer

File:

Download XAC-Thesis-20151209-2.pdf

Committee Members:

Yanming Wang, Dissertation Advisor/Co-Advisor
Douglas Cavener, Committee Chair/Co-Chair
Zhi Chun Lai, Committee Member
Lu Bai, Committee Member
Gavin Peter Robertson, Special Member

Author:

Li, Sixing

Title:

Application of acoustofluidic technologies in cell biology

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

microfluidics
acoustofluidic
surface acoustic wave
cell biology
virology
single-cell analysis

File:

Download Sixing_Li_PhD_Dissertation_final.pdf

Committee Members:

Jun Huang, Dissertation Advisor/Co-Advisor
Craig Eugene Cameron, Dissertation Advisor/Co-Advisor
Jun Huang, Committee Chair/Co-Chair
Craig Eugene Cameron, Committee Chair/Co-Chair
Andrea Marie Mastro, Committee Member
Gong Chen, Committee Member

Author:

Fu, Yaoyao

Title:

Roles Of CCR10 in establishment and maintenance of skin T cell homeostasis

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

CCR10
CD8+
Treg
skin homeostasis

File:

Download Yaoyao_FU_dissertation.pdf

Committee Members:

Na Xiong, Dissertation Advisor/Co-Advisor
Na Xiong, Committee Chair/Co-Chair
Liwang Cui, Committee Member
Pamela Hankey Giblin, Committee Member
Girish Soorappa Kirimanjeswara, Committee Member

Author:

Wang, Qingyu

Title:

Evaluation of whole exome sequencing technology in cohort dataset and quantification of phenotypic alterations in a model organism

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Whole Exome Sequencing
low coverage
unevenness
Drosophila melanogaster
eye phenotype
image processing
quantitative assessment

File:

Download QWFinal_dissertation.pdf

Committee Members:

Naomi S Altman, Dissertation Advisor/Co-Advisor
Santhosh Girirajan, Dissertation Advisor/Co-Advisor
Ross Cameron Hardison, Committee Member
Shaun A Mahony, Committee Member
Cooduvalli S Shashikant, Committee Member

Author:

Jenkins, Brenita Colette

Title:

Examining the role of α6β2* nicotinic acetylcholine receptors on ethanol-induced behavioral responses in adolescent C57BL/6J mice

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Ethanol
nicotinic acetylcholine receptors
adolescence
mice
bPiDI
consumption
ataxia
sedation

File:

Download Brenita_C._Jenkins_-_Master_Thesis_2015_Penn_State.pdf

Committee Members:

Helen Kamens, Thesis Advisor/Co-Advisor

Author:

Wang, Fan

Title:

Developing hippocampal delivery of AAV-NeuroD1 as a novel therapy for Alzheimer's disease

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Alzheimer's disease
NeuroD1
hippocampus
AAV

File:

Download 1-Thesis-Fan_Wang-final2.pdf

Committee Members:

Gong Chen, Thesis Advisor/Co-Advisor
Bernhard Luscher, Thesis Advisor/Co-Advisor
Richard W Ordway, Thesis Advisor/Co-Advisor
Yingwei Mao, Thesis Advisor/Co-Advisor

Author:

Rebolledo Jaramillo, Boris Eduardo

Title:

Understanding mitochondrial DNA and RNA variability in humans

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

mitochondria
heteroplasmy
germ-line bottleneck
mitochondrial RNA
mtDNA

File:

Download ber5099_IBIOS-BG_dissertation_2016.pdf

Committee Members:

Anton Nekrutenko, Dissertation Advisor/Co-Advisor
Kateryna Dmytrivna Makova, Committee Member
Francesca Chiaromonte, Committee Member
Michael Degiorgio, Committee Member

Author:

Awani, Awani

Title:

Nicotinamide is a TRPV channel agonist in Caenorhabditis elegans and Drosophila melanogaster

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

TRPV
ION CHANNEL
C ELEGANS
NICOTINAMIDE
CELL DEATH

File:

Download Revised_Dissertation__Awani__12.13.16.pdf

Committee Members:

Wendy Hanna Rose, Dissertation Advisor/Co-Advisor

Author:

Heldenbrand, Jacob Ray

Title:

Transcriptional interference drives the evolution of mammalian nested genes

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

nested genes
interference
evolution

File:

Download MastersThesis_final.pdf

Committee Members:

Raquel Assis, Thesis Advisor/Co-Advisor
Stephen Wade Schaeffer, Committee Member
Shaun A Mahony, Committee Member

Author:

Lewis, Carrie Rebekah

Title:

THE REGULATION OF ER CHAPERONES AND PROINSULIN PROTEOSTASIS BY PERK EIF2ALPHA KINASE

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

proinsulin
ER chaperones
PERK
EIF2AK3

File:

Download CL_Thesis_Dissertation_FINAL_edited_with_corrections_7-14-16.pdf

Committee Members:

Douglas Cavener, Dissertation Advisor/Co-Advisor
Melissa Rolls, Committee Chair/Co-Chair
Zhi-Chun Lai, Committee Member
Douglas Cavener, Committee Member
Yanming Wang, Outside Member

Author:

Hariharan, Sneha

Title:

STUDY OF GROWTH OF STRESS ERYTHROID PROGENITORS FROM PERIPHERAL BLOOD MONONUCLEAR CELLS IN MURINE AND HUMAN ANEMIC MODEL SYSTEMS.

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Stress erythropoiesis
erythroid progenitor migration
Sickle cell disease
acute anemia

File:

Download Sneha_Masters_Thesis_2016.pdf

Committee Members:

Robert Paulson, Thesis Advisor/Co-Advisor
K. Sandeep Prabhu, Committee Member
Pamela A. Hankey, Committee Member

Author:

sun, jinquan

Title:

A NOVEL SMALL MOLECULE DNA INTERCALATOR PZ1225 IN CANCER CELL APOPTOSIS AND A HISTONE MODIFIER PAD4 IN MACROPHAGE EXTRACELLULAR TRAP FORMATION

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

DNA damage
DNA intercalator
small molecule
MAPK
mTOR
apoptosis
macrophage
extracellular traps
PAD4
citrullination
stroke

File:

Download Graduation_Thesis-Jinquan-20161201.pdf

Committee Members:

Yanming Wang, Dissertation Advisor/Co-Advisor
Zhi-Chun Lai, Committee Chair/Co-Chair
Douglas Cavener, Committee Member
Lu Bai, Committee Member
Robert Paulson, Outside Member

Author:

Jiang, Dongyun

Title:

A novel mouse model with neuroligin-2 R215H mutation for the study of psychiatric disorders

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

neuroligin 2
R215H mutation
schizophrenia
psychiatric disorders
GABAergic deficits

File:

Download PS-Thesis-Dongyun_Jiang.pdf

Committee Members:

Gong Chen, Dissertation Advisor/Co-Advisor
Gong Chen, Committee Chair/Co-Chair
Bernhard Luscher, Committee Member
Yingwei Mao, Committee Member
Nanyin Zhang, Outside Member
Aimin Liu, Committee Member

Author:

Cai, Hongchen

Title:

Genetic Analysis Reveals Dual Roles of Speckle-type Poz Protein in Hedgehog Signaling And Mouse Development

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Ubiquitination
Gli3
Skeletal development
osteoporosis
spinal cord patterning

File:

Download Dissertation_HongchenCai_Final.pdf

Committee Members:

Aimin Liu, Dissertation Advisor/Co-Advisor
Aimin Liu, Committee Chair/Co-Chair
Douglas Cavener, Committee Member
Yingwei Mao, Committee Member
Andrea Mastro, Outside Member

Author:

Nisic, Merisa

Title:

PHENOTYPIC AND GENETIC CHARACTERIZATION OF NON-SMALL CELL LUNG CANCER CIRCULATING TUMOR CELLS

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Circulating Tumor Cell
Enrichment
Microfiltration
Lung Cancer

File:

Download Merisa_Nisic_Dissertation_FINAL.pdf

Committee Members:

Siyang Zheng, Dissertation Advisor/Co-Advisor
Siyang Zheng, Committee Chair/Co-Chair
Jian Yang, Committee Member
Zhi-Chun Lai, Committee Member
Andrea Marie Mastro, Outside Member

Author:

Matsui, Yurika

Title:

THE FUNCTION AND REGULATION OF A TRANSCRIPTIONAL CO-ACTIVATOR YAP IN GROWTH CONTROL AND TISSUE HOMEOSTASIS

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Hippo pathway
Yes-associated protein (YAP)
cell proliferation
apoptosis
isoform
pancreatic beta-cell
large tumor suppressor kinase 1 (LATS1)

File:

Download PhDdissertation_YurikaMatsui.pdf

Committee Members:

Zhi-Chun Lai, Dissertation Advisor/Co-Advisor
Douglas Cavener, Committee Chair/Co-Chair
Melissa Rolls, Committee Member
Michael Axtell, Committee Member
Lorraine C Santy, Outside Member

Author:

Yang, Xiaoxu

Title:

Investigating the roles of primary cilium in Gli protein activation and Hedgehog signaling pathway using Sufu/Gli ciliary recruitment system

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Hh signaling
Sufu
Gli2
primary cilia

File:

Download Master_Thesis_Xiaoxu_Yang.pdf

Committee Members:

Aimin Liu, Thesis Advisor/Co-Advisor
Xiong Na, Committee Member
Adam Bleier Glick, Committee Member

Author:

Zhou, Yijing

Title:

Interactome analysis reveals ZNF804A, a schizophrenia risk gene, as a novel component of protein translational machinery critical for embryonic neurodevelopment

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

schizophrenia

File:

Download Dissertation_Yijing_Zhou_final.pdf

Committee Members:

Yingwei Mao, Dissertation Advisor/Co-Advisor
Yingwei Mao, Committee Chair/Co-Chair
Timothy J Jegla, Committee Member
Gong Chen, Committee Member
Wendy Hanna-Rose, Outside Member

Author:

Chen, Yuchen

Title:

CONVERSION OF REACTIVE GLIA INTO FUNCTIONAL NEURONS AS A NOVEL THERAPY FOR STROKE

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

NeuroD1
ischemic injury
brain repair
astrocyte-to-neuron conversion
motor function

File:

Download PhD_Thesis_Yuchen_20180414.pdf

Committee Members:

Gong Chen, Dissertation Advisor/Co-Advisor
Yingwei Mao, Committee Chair/Co-Chair
Timothy J Jegla, Committee Member
Bernhard Luscher, Committee Member
Ian Alexander Simpson, Outside Member

Author:

Zhu, Xiaoyu

Title:

THE IDENTIFICATION AND CHARACTERIZATION OF REGULATORS OF PLANT EXOCYTOSIS AND THEIR ROLES IN CELLULOSE BIOSYNTHESIS

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

cellulose synthase complex
exocytosis
exocyst complex
microtubule

File:

Download Xiaoyu_Zhu_Ph.D._Dissertation.pdf

Committee Members:

Ying Gu, Dissertation Advisor/Co-Advisor
Ying Gu, Committee Chair/Co-Chair
Yanming Wang, Committee Member
Michael Axtell, Committee Member
Gabriele Brigitte Monshausen, Outside Member

Author:

Kaiser, Theodora Alexis

Title:

MOLECULAR AND EVOLUTIONARY ANALYSES OF TRANSCRIPTIONALLY ACTIVE ENDOGENOUS RETROVIRUSES IN MULE DEER

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

endogenous retrovirus
insertional polymorphism
transcription
mule deer
gene expression
population differences

File:

Download TKaiser_Dissertation_71018.pdf

Committee Members:

Mary Poss, Dissertation Advisor/Co-Advisor
Mary Poss, Committee Chair/Co-Chair
Cooduvalli S Shashikant, Committee Member
Michael Axtell, Committee Member
Le Bao, Outside Member

Author:

Campbell, Alexander Michael

Title:

INTERCONTINENTAL PHYLOGEOGRAPHY OF FUSARIUM SOLANI SPECIES COMPLEX ASSOCIATED WITH AN INVASIVE XYLOPHAGOUS CERAMBYCID

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Asian longhorned beetle
Anoplophora glabripennis
Fusarium solani
invasive species
phylogeny

File:

Download Msci_thesis_final071318.pdf

Committee Members:

Kelli Hoover, Thesis Advisor/Co-Advisor
David Geiser, Committee Member
Margarita López-Uribe, Committee Member

Author:

Brittingham, Jacob Charles

Title:

CHARACTERIZATION OF PDX1 AND ITS INTERACTIONS WITH SPOP

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

PDX1
SPOP

File:

Download Emerging_role_of_intrinsically_disordered_protein_regions.pdf

Committee Members:

Scott A Showalter, Thesis Advisor/Co-Advisor
Melissa Rolls, Committee Member
Lorraine C Santy, Committee Member

Author:

Shi, Lai

Title:

PAD4 MEDIATED CANCER EXTRACELLULAR CHROMATIN NETWORK IN BREAST CANCER PROMOTES THE DEVELOPMENT AND PROGRESSION OF LUNG METASTASIS

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

PAD4
Hypercitrullination
Cancer Extracellular Chromatin Network
Breast cancer
Lung metastasis

File:

Download Dissertation-Lai_Shi.pdf

Committee Members:

Yanming Wang, Dissertation Advisor/Co-Advisor
Yong Wang, Committee Chair/Co-Chair
Siyang Zheng, Committee Member
Yanming Wang, Committee Member
Robert Paulson, Outside Member

Author:

Lu, Feiyue

Title:

MOLECULAR ANALYSES OF THE DROSOPHILA RNA POLYMERASE II CARBOXY-TERMINAL DOMAIN

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

RNA Pol II CTD
consensus heptads
divergent motifs
transcription compartment
Drosophila genetics

File:

Download Lu_thesis_final_final.pdf

Committee Members:

David Scott Gilmour, Dissertation Advisor/Co-Advisor
David Scott Gilmour, Committee Chair/Co-Chair
Benjamin Franklin Pugh, Committee Member
Melissa Rolls, Committee Member
Scott A Showalter, Outside Member
Joseph C. Reese, Committee Member
Claire Madison Thomas, Committee Member

Author:

Kuzu, Gulsum

Title:

SELECTIVE ACTIVATION OF THE ARYL HYDROCARBON RECEPTOR IN MODULATING LIPID HOMEOSTASIS

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

aryl hydrocarbon receptor
selective ligands
cholesterol
sterol regulatory element binding protein
fatty acid synthesis

File:

Download Kuzu_Gulsum_Dissertation_final_.pdf

Committee Members:

Gary H Perdew, Dissertation Advisor/Co-Advisor
Gary H Perdew, Committee Chair/Co-Chair
Andrew David Patterson, Committee Member
Adam Bleier Glick, Committee Member
Frank Dorman, Outside Member

Author:

Schilling, Megan

Title:

Transcriptional Responses of Innate Immune Genes in the Developing Chick Embryo of Inbred and Outbred Lines to Newcastle Disease Virus Infection

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Newcastle disease virus
chick embryo
NDV
Tanzania
innate immunity
ecotypes

File:

Download Schilling-Dissertation.pdf

Committee Members:

Vivek Kapur, Dissertation Advisor/Co-Advisor
Vivek Kapur, Committee Chair/Co-Chair
Isabella Cattadori, Committee Member
Suresh Varma Kuchipudi, Committee Member
Bhushan M Jayarao, Outside Member

Author:

Hao, Siyang

Title:

Regulation of stress erythropoiesis via splenic erythroid microenvironment development and metabolic programming

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

stress erythropoiesis
splenic erythroid niche
cellular metabolism
growth-differentiation factor 15
glucocorticoids
Yes-associated protein

File:

Download Siyang_Hao_dissertation_.pdf

Committee Members:

Robert F. Paulson, Dissertation Advisor/Co-Advisor
Zhi-Chun Lai, Committee Chair/Co-Chair
K. Sandeep Prabhu, Committee Member
Andrew D. Patterson, Committee Member
Xiaojun (Lance) Lian, Outside Member

Author:

Hudson, Chelsea

Title:

Elucidating the Genetic Changes Underlying Giraffe’s Unique Phenotypes

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Giraffe

File:

Download Chelsea_Hudson_Thesis.pdf

Committee Members:

Douglas Cavener, Thesis Advisor/Co-Advisor
Aimin Liu, Committee Member
Zhi-Chun Lai, Committee Member

Author:

Feng, Mengyang

Title:

ELUCIDATION OF MECHANISMS THAT DETERMINE THE RESPONSIVENESS TO ANTIDEPRESSANT DRUG TREATMENTS

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Depression
Antidepressant
Neuroinflammation
High fat diet
Obesity
Ketamine

File:

Download MengyangFeng_Dissertation.pdfDownload Mengyang_Feng_Erratum.pdf

Committee Members:

Bernhard Luscher, Dissertation Advisor/Co-Advisor
Bernhard Luscher, Committee Chair/Co-Chair
Melissa Rolls, Committee Member
Timothy J Jegla, Committee Member
Pamela Hankey Giblin, Outside Member
Jeffrey Maurice Peters, Committee Member

Author:

Jiang, Xueyuan

Title:

Sequence and Expression Evolution of Animal and Plant Genes

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Sequence evolution; Expression evolution

File:

Download Xueyuan_Jiang_Dissertation.pdf

Committee Members:

Raquel Assis, Dissertation Advisor/Co-Advisor
Stephen Wade Schaeffer, Committee Chair/Co-Chair
Shaun Mahony, Committee Member
Yifei Huang, Committee Member
Qunhua Li, Outside Member
Melissa Rolls, Program Head/Chair
Raquel Assis, Committee Chair/Co-Chair
Stephen Wade Schaeffer, Dissertation Advisor/Co-Advisor

Author:

Hu, Kai

Title:

Bioinformatics discovery of chemical diversity in enzyme superfamilies

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Ribonucleotide Reductase (RNR)
Bioinformatics
Radical chemistry
Class Ie RNR
Deep Mutational Scanning (DMS) strategy

File:

Download Kai_Hu_dissertation_for_submission.pdf

Committee Members:

Benjamin D Allen, Dissertation Advisor/Co-Advisor
Joseph M Bollinger, Jr., Committee Chair/Co-Chair
Amie Kathleen Boal, Outside Member
Ross Cameron Hardison, Committee Member
Melissa Rolls, Program Head/Chair

Author:

Venkatachalam Srinivasan, Sreenidhi

Title:

Improved diagnosis and control of Bovine Tuberculosis

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Bovine Tuberculosis
endemic
diagnosis
vaccine

File:

Download Thesis_04132020.pdf

Committee Members:

Vivek Kapur, Dissertation Advisor/Co-Advisor
Vivek Kapur, Committee Chair/Co-Chair
P Hudson, Committee Member
Suresh Varma Kuchipudi, Committee Member
Erika Korzune Ganda, Outside Member
Melissa Rolls, Program Head/Chair

Author:

Wang, Xin

Title:

neuronal conversion of human glioblastoma cells by single neuronal transcription factor

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

neuronal conversion
Neurog2
NeuroD1
Ascl1
glioblastoma

File:

Download Dissertation_Xin.pdf

Committee Members:

Yingwei Mao, Dissertation Advisor/Co-Advisor
Yingwei Mao, Committee Chair/Co-Chair
Timothy J Jegla, Committee Member
Xiaojun Lance Lian, Committee Member
Adam Bleier Glick, Outside Member
Gong Chen, Committee Chair/Co-Chair
Gong Chen, Dissertation Advisor/Co-Advisor
Melissa Rolls, Program Head/Chair

Author:

Jiang, Haoyang

Title:

CHARACTERIZATION OF THE FUNCTIONS OF THE CCR4-NOT COMPLEX IN DNA DAMAGE RESPONSE

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Ccr4-Not complex
RNAPII ubiquitination
Transcription and DNA damage repair

File:

Download Haoyang_Jiang_Thesis-V12.pdf

Committee Members:

Joseph C. Reese, Dissertation Advisor/Co-Advisor
Joseph C. Reese, Committee Chair/Co-Chair
David Scott Gilmour, Committee Member
Ross Cameron Hardison, Committee Member
Tae-Hee Lee, Outside Member
Melissa Rolls, Program Head/Chair

Author:

Weiner, Alexis

Title:

Dendritic Microtubule Polarity is Maintained by Kinesin-2 Steering and Positioning of Nucleation Sites by Endosomal Wnt Signaling Proteins

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

neurons
microtubules
nucleation
APC2
gTub
dendrite

File:

Download Dissertation_AW.pdf

Committee Members:

Melissa Rolls, Dissertation Advisor/Co-Advisor
Melissa Rolls, Committee Chair/Co-Chair
Timothy J Jegla, Committee Member
Lorraine C Santy, Committee Member
William O Hancock, Outside Member
Melissa Rolls, Program Head/Chair

Author:

Feng, Qingzhou

Title:

Motor dynamics underling bidirectional cargo transport by kinesin and dynein

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

kinesin
dynein
microtubule
bidirectional transport

File:

Download Thesis_May2020QF.pdf

Committee Members:

William O Hancock, Dissertation Advisor/Co-Advisor
Melissa Rolls, Committee Member
Lu Bai, Committee Member
Charles T Anderson, Committee Member
Christopher Martin Yengo, Outside Member
Melissa Rolls, Program Head/Chair
William O. Hancock, Committee Chair/Co-Chair

Author:

Chen, Yuanting

Title:

NOVEL SIGNALS IN STRESS ERYTHROPOIESIS: COORDINATED CONTROL OF WNT, PGE2 AND PERK SIGNALING PATHWAYS REGULATES EXPANSION AND DIFFERENTIATION OF STRESS ERYTHROID PROGENITORS

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Stress erythropoiesis
Wnt
PGE2
PERK
mTORC1

File:

Download Thesis_2nd_Yuanting_Chen.pdf

Committee Members:

Robert Paulson, Dissertation Advisor/Co-Advisor
Robert Paulson, Committee Chair/Co-Chair
Kumble Sandeep Prabhu, Committee Member
Zhi-Chun Lai, Committee Member
Xiaojun Lance Lian, Outside Member
Wendy Hanna-Rose, Committee Member
Melissa Rolls, Program Head/Chair

Author:

Feng, Chengye

Title:

Investigation of microtubule polarity regulation in dendrites of drosophila sensory neurons

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

microtubule polarity
Patronin
Trim9
kinesin-5
dendrite development
dynamic instability

File:

Download Thesis_draft_Chengye_Feng_Spring_2020_final.pdf

Committee Members:

Melissa Rolls, Dissertation Advisor/Co-Advisor
Melissa Rolls, Committee Chair/Co-Chair
Yingwei Mao, Committee Member
Richard W Ordway, Committee Member
William O Hancock, Outside Member
Melissa Rolls, Program Head/Chair

Author:

Harris, Alexandre

Title:

Improved methods for detecting, quantifying, and classifying genetic diversity in natural populations

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Unbiased estimator
Haplotype
Multilocus genotype
Selective sweep
Maximum likelihood
Soft sweep

File:

Download Harris_thesis_2020_main_rebuild.pdf

Committee Members:

Michael DeGiorgio, Dissertation Advisor/Co-Advisor
Stephen Wade Schaeffer, Committee Chair/Co-Chair
George H Perry, Committee Member
Michael DeGiorgio, Committee Chair/Co-Chair
Paul Medvedev, Outside Member
Melissa Rolls, Program Head/Chair
Stephen Wade Schaeffer, Dissertation Advisor/Co-Advisor

Author:

Cheng, Xiaoheng

Title:

Detecting Footprints of Ancient Natural Selection from Population Genomic Data

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Natural selection
Population genetics
Balancing selection
Maximum likelihood ratio
Adaptation
Great apes

File:

Download Cheng_Dissertation_final2.pdf

Committee Members:

Michael DeGiorgio, Dissertation Advisor/Co-Advisor
Stephen Wade Schaeffer, Committee Chair/Co-Chair
George H Perry, Committee Member
Michael DeGiorgio, Committee Chair/Co-Chair
Le Bao, Outside Member
Melissa Rolls, Program Head/Chair
Stephen Wade Schaeffer, Dissertation Advisor/Co-Advisor

Author:

Johnson, Rebecca

Title:

Anopheles gambiae densovirus as a viral vector for the expression of small RNAs and transgenes

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Anopheles gambiae
Densovirus
microRNA
autophagy
viral expression vector

File:

Download RJohnson_Thesis.pdf

Committee Members:

Jason Laurence Rasgon, Dissertation Advisor/Co-Advisor
Jason Laurence Rasgon, Committee Chair/Co-Chair
Scott Eugene Lindner, Committee Member
Michael Axtell, Committee Member
Marilyn J Roossinck, Outside Member
Melissa Rolls, Program Head/Chair

Author:

Wang, Yue

Title:

MECHANISTIC STUDY OF ALZHEIMER’S DISEASE AND NEUROD1-MEDIATED IN VIVO CELL CONVERSION

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Alzheimer's disease
NeuroD1
Cell conversion
Beneficial effect
GAD67
Haploinsufficiency
Small molecule cocktail
Therapy
In vivo

File:

No files available due to restrictions.

Committee Members:

Gong Chen, Dissertation Advisor/Co-Advisor
Douglas Cavener, Committee Chair/Co-Chair
Bernhard Luscher, Committee Member
Kevin Douglas Alloway, Committee Member
Yingwei Mao, Outside Member

Author:

Hu, Jingjie

Title:

Co-opting regulation bypass repair (CRBR) as gene editing strategy in mouse and human pancreatic beta cells

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

CRISPR/Cas9
gene editing
CRBR
monogenic disease
rare disease
Wolcott-Rallison syndrome
PERK(EIF2AK3)
Insulin
diabetes

File:

Download J_Hu_Dissertation_Final_3-24-2021.pdf

Committee Members:

Douglas Cavener, Dissertation Advisor/Co-Advisor
Douglas Cavener, Committee Chair/Co-Chair
Zhi-Chun Lai, Committee Member
Yingwei Mao, Committee Member
Melissa Rolls, Outside Member
Timothy J Jegla, Committee Member
Melissa Rolls, Program Head/Chair

Author:

Walker, Michael

Title:

Development and Implementation of a Novel CRISPR/Cas9 System to Investigate Translational Repression Mechanisms in Plasmodium yoelii.

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Malaria
CRISPR
Plasmodium
yoelii
TRIBE
Translational Repression
RNA
DNA
RGR

File:

Download Michael_P._Walker_Dissertation-Finalformat.pdf

Committee Members:

Scott E. Lindner, Dissertation Advisor/Co-Advisor
Scott E. Lindner, Committee Chair/Co-Chair
Melissa Rolls, Committee Member
Manuel Llinas, Committee Member
Howard M Salis, Outside Member
Maciej F Boni, Committee Member
Melissa Rolls, Program Head/Chair

Author:

Nye, Derek Michael

Title:

Intrinsic Mechanisms of Neuronal Remodeling: Degeneration and Repair in Drosophila Sensory Neurons

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Drosophila
Dendrite Regeneration
Axon Degeneration
Neurons
Cell Biology
Genetics
Neurobiology
Model organism
Neuroscience

File:

Download thesis_V13_reformatted_combined.pdf

Committee Members:

Melissa Rolls, Dissertation Advisor/Co-Advisor
Melissa Rolls, Committee Chair/Co-Chair
Santosh Girirajan, Committee Member
Richard W Ordway, Outside Member
Shaun Mahony, Committee Member
Charles H Lang, Committee Member
Melissa Rolls, Program Head/Chair

Author:

Goetschius, Daniel

Title:

Icosahedral Subparticle Extraction & Correlated Classification: Characterizing Heterogeneities in Icosahedral Viruses

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

human papillomavirus
polyomavirus
parvovirus
virology
electron microscopy
zika virus
structural biology
structural virology
cryo electron microscopy
cryoEM

File:

Download Goetschius_v8_no_highlights_corrected.pdf

Committee Members:

Susan Hafenstein, Dissertation Advisor/Co-Advisor
Susan Hafenstein, Committee Chair/Co-Chair
Song Tan, Committee Member
Aron Eliot Lukacher, Committee Member
Matthew T Swulius, Outside Member
Joyce Jose, Committee Member
Melissa Rolls, Program Head/Chair