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1. MECHANISTIC STUDIES OF THE METHYLTHIOLATION REACTION CATALYZED BY THE RADICAL SAM ENZYME RIMO

open_access
Open Access
Author:
Landgraf, Bradley James
Title:
MECHANISTIC STUDIES OF THE METHYLTHIOLATION REACTION CATALYZED BY THE RADICAL SAM ENZYME RIMO
Graduate Program:
Chemistry
Keywords:
S-adenosylmethionine
Radical SAM
Methylthiotransferase
Enzymology
5'-deoxyadenosyl radical
S-adenosylhomocysteine
Post-translational modification
File:
Download Landgraf_Final_Dissertation_2.pdf
Committee Members:
Squire J. Booker, Dissertation Advisor/Co-Advisor
Squire J Booker, Committee Chair/Co-Chair
Carsten Krebs, Committee Member
Amie Kathleen Boal, Committee Member
William O Hancock, Outside Member

2. Mechanistic Analysis of the Radical SAM Methylases RlmN and Cfr

open_access
Open Access
Author:
Bauerle, Matthew Richard
Title:
Mechanistic Analysis of the Radical SAM Methylases RlmN and Cfr
Graduate Program:
Chemistry
Keywords:
Radical SAM enzyme
Mechanistic Enzymology
X-ray Crystallography
RlmN and Cfr
Mass Spectrometry
Electron Paramagnetic Resonance (EPR) spectroscopy
Enzyme Kinetics
Rapid Chemical Quench
pH-rate profile
Deuterium Exchange
Directed Evolution
Methylation
Thiyl Radical
Cysteine
Iron-Sulfur Cluster
S-adenosylmethionine
5'-deoxyadenosine
S-adenosylhomocysteine
Radical SAM methylase
File:
Download Bauerle_Thesis_Final.pdf
Committee Members:
Dr. Squire J. Booker, Dissertation Advisor/Co-Advisor
Dr. Squire J. Booker, Committee Chair/Co-Chair
Dr. Amie K. Boal, Committee Member
Dr. J. Martin Bollinger, Committee Member
Dr. William Hancock, Outside Member
Dr. Carsten Krebs, Committee Member