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Author:

Bounds, Callie E

Title:

AN INVESTIGATION OF THE VACCINE GENERATED CELL MEDIATED IMMUNE RESPONSES TO HLA-A2.1 RESTRICTED HPV16E7 EPITOPES IN VIVO USING TWO PRECLINICAL ANIMAL MODELS

Graduate Program:

Microbiology and Immunology

Keywords:

Gene Gun
HLA-A2.1 Rabbits
DNA Vaccines
CRPV
HPV
HHD mice

File:

Download Final-Thesis.pdf

Committee Members:

Neil David Christensen, Dissertation Advisor/Co-Advisor
Neil David Christensen, Committee Chair/Co-Chair
Todd Schell, Committee Member
Craig Matthew Meyers, Committee Member
David Joseph Spector, Committee Member
Laura Carrel, Committee Member

Author:

Park, Chungoo

Title:

STUDIES OF GENE EXPRESSION EVOLUTION: GENES ON THE INACTIVE X CHROMOSOME AND DUPLICATE GENES

Graduate Program:

Biology

Keywords:

X CHROMOSOME INACTIVATION. GENE DUPLICATION

File:

Download Ph_D_Thesis_Chungoo_Park_2010_Final.pdf

Committee Members:

Kateryna Dmytrivna Makova, Dissertation Advisor/Co-Advisor
Kateryna Dmytrivna Makova, Committee Chair/Co-Chair
Laura Carrel, Committee Member
Francesca Chiaromonte, Committee Member
Webb Colby Miller, Committee Member
Claude Walker Depamphilis, Committee Member

Author:

Bulynko, Yaroslava

Title:

Role of Cysteine Protease Cathepsin L in Maintenance of Epigenetic Histone Modifications and Constitutive Heterochromatin

Graduate Program:

Biochemistry and Molecular Biology

Keywords:

histone modifications
protease
chromatin

File:

Download Thesis_Bulynko.pdf

Committee Members:

Sergei A Grigoryev, Committee Chair/Co-Chair
Laura Carrel, Committee Member
Momcilo Miljkovic, Committee Member
Vincent Chau, Committee Member
Judith S Bond, Committee Member

Author:

Petko, Jessica Ann

Title:

MOLECULAR DETERMINATION OF NOVEL GENES AND PATHWAYS REQUIRED FOR VESTIBULAR MORPHOGENESIS IN ZEBRAFISH

Graduate Program:

Genetics

Keywords:

semicircular canal
balance
ncs-1
otoc1
inner ear
zebrafish
otolith

File:

Download Master.pdf

Committee Members:

Robert G Levenson, Committee Chair/Co-Chair
Laura Carrel, Committee Member
Keith C Cheng, Committee Member
Victor Alan Canfield, Committee Member

Author:

Maddox, Jacquelyln Renee

Title:

Evaluation of Putative Cell Surface Markers That Characterize Human and Murine Adipose Derived Stem Cells

Graduate Program:

Biochemistry and Molecular Biology

Keywords:

bone formation
stem cell marker
mesenchymal stem cell
adipose derived stem cell
SSEA-4
osteogenic

File:

Download Final_Thesis.pdf

Committee Members:

Christopher Niyibizi, Dissertation Advisor/Co-Advisor
Christopher Niyibizi, Committee Chair/Co-Chair
Laura Carrel, Committee Member
Henry Joseph Donahue, Committee Member
Cara Lynne Schengrund, Committee Member
Kent Eugene Vrana, Committee Member

Author:

Prothero, Katie Eva

Title:

Identification of a CTCF-independent insulator that delimits X-inactivated from expressed transcripts within the UBA1 gene

Graduate Program:

Biochemistry and Molecular Biology

Keywords:

DNA methylation
X chromosome inactivation
epigenetics

File:

Download Prothero_Thesis_FINAL2.pdf

Committee Members:

Laura Carrel, Dissertation Advisor/Co-Advisor
Laura Carrel, Committee Chair/Co-Chair
Sergei A Grigoryev, Committee Member
Ira Joseph Ropson, Committee Member
Jiyue Xhu, Committee Member

Author:

Ludgate, Laurie

Title:

Regulation of hepadnavirus core protein function by phosphorylation

Graduate Program:

Microbiology and Immunology

Keywords:

HBV
DHBV
core protein
phosphorylation
kinase

File:

Download Ludgate_Final_doc.pdf

Committee Members:

Jianming Hu, Dissertation Advisor/Co-Advisor
Jianming Hu, Committee Chair/Co-Chair
Rebecca C Craven, Committee Member
David Joseph Spector, Committee Member
Harriet C Isom, Committee Member
Laura Carrel, Committee Member

Author:

Wilson Sayres, Melissa Ann

Title:

Mammalian genome evolution through the lens of the sex chromosomes

Graduate Program:

Integrative Biosciences

Keywords:

evolution
genomes
evolution
sex chromosomes
mammals

File:

Download WilsonSayres_final_dissertation.pdf

Committee Members:

Kateryna Dmytrivna Makova, Dissertation Advisor/Co-Advisor
Kateryna Dmytrivna Makova, Committee Chair/Co-Chair
Webb Colby Miller, Committee Member
Stephen Wade Schaeffer, Committee Member
Eddie Holmes, Committee Member
Laura Carrel, Committee Member

Author:

Tran, Melissa Ann

Title:

TREATMENT OF MELANOMA AND BREAST CANCER WITH GENETIC BASED LIPOSOMAL DRUG FORMULATIONS

Graduate Program:

Genetics

Keywords:

siRNA
liposomes
melanoma
ultrasound

File:

Download Melissa_Tran_Thesis_Revised.pdf

Committee Members:

Gavin Peter Robertson, Committee Chair/Co-Chair
Craig Matthew Meyers, Committee Member
Laura Carrel, Committee Member
Jiyue Zhu, Committee Member
Thomas Loughran, Committee Member

Author:

Chandy, Mark

Title:

HISTONE MODIFICATIONS INFLUENCE CHROMATIN MODIFYING AND CHROMATIN REMODELING COMPLEXES

Graduate Program:

Biochemistry and Molecular Biology

Keywords:

SAGA
SWI/SNF
chromatin remodeling
bromodomain

File:

Download ThesisMaster.pdf

Committee Members:

James E Hopper, Committee Chair/Co-Chair
Sergei A Grigoryev, Committee Member
Michael G Fried, Committee Member
Laura Carrel, Committee Member
Jerry L Workman, Committee Chair/Co-Chair
Robert G Levenson, Committee Member

Author:

Keasey, Nikki R

Title:

AMINO ACID PERMEASE INVOLVEMENT IN THE VOLATILE ANESTHETIC RESPONSE OF SACCHAROMYCES CEREVISIAE

Graduate Program:

Biochemistry and Molecular Biology

Keywords:

yeast
volatile anesthetics
nutrient transport

File:

Download Microsoft_Word_-_Nikki_Keasey_thesis_FINAL.doc.pdf

Committee Members:

Ralph Lauren Keil, Committee Chair/Co-Chair
Jong Kak Yun, Committee Member
Leonard Shelton Jefferson Jr., Committee Member
Laura Carrel, Committee Member
Ross Shiman, Committee Member
Scot R Kimball, Committee Member

Author:

Li, Nan

Title:

ESCAPE FROM X CHROMOSOME INACTIVATION IS AN INTRINSIC PROPERTY OF THE MOUSE JARID1C LOCUS

Graduate Program:

Genetics

Keywords:

X chromosome inactivation
epigenetics
transgene
embryonic stem cell

File:

Download Thesis-Nan_Li.pdf

Committee Members:

Laura Carrel, Dissertation Advisor/Co-Advisor
Laura Carrel, Committee Chair/Co-Chair
Sarah Bronson, Committee Member
Sergei A Grigoryev, Committee Member
Kent Eugene Vrana, Committee Member
Teresa L Wood, Committee Member

Author:

Balliet, Renee Marie

Title:

CHARACTERIZATION OF UGTS ACTIVE AGAINST SUBEROYLANILIDE HYDROXAMIC ACID (SAHA): VARIATIONS IN SAHA GLUCURONIDATION ASSOCIATED WITH UGT GENETIC VARIANTS

Graduate Program:

Genetics

Keywords:

SAHA
pharmacogenetic
UGT

File:

Download Renee_Balliet_Final_Dissertation.pdf

Committee Members:

Philip Lazarus, Dissertation Advisor/Co-Advisor
Philip Lazarus, Committee Chair/Co-Chair
Laura Carrel, Committee Member
Lisa M Shantz, Committee Member
Christopher Herzog, Committee Member

Author:

Correll, Sarah Jane

Title:

Molecular and Structural Determinants of Chromatin Folding

Graduate Program:

Genetics

Keywords:

linker histone
nucleosome
chromatin structure
analytical ultracentrifugation

File:

Download Correll_Sarah_Final_Thesis.pdf

Committee Members:

Sergei A Grigoryev, Dissertation Advisor/Co-Advisor
Kristin Ann Eckert, Committee Member
Sarah Bronson, Committee Member
Laura Carrel, Committee Member
Sergei A Grigoryev, Committee Chair/Co-Chair
Jiyue Zhu, Committee Member

Author:

Chakraborty, Sangita Abid

Title:

Construction and characterization of a minichromosome reporter system to study structure-function relationship between gene silencing and chromatin boundaries in Saccharomyces cerevisiae

Graduate Program:

Biochemistry and Molecular Biology

Keywords:

Chromatin
Heterochromatin
Boundary
Barrier
anti-silencer
gene silencing
URA3
601 nucleosome
Minichromosome
Yeast

File:

Download Sangita_Dissertation_Final_eTD_05012012_upload_0786_PDF.pdf

Committee Members:

Sergei A Grigoryev, Dissertation Advisor/Co-Advisor
Sergei A Grigoryev, Committee Chair/Co-Chair
Laura Carrel, Committee Member
Ralph Lauren Keil, Committee Member
Avery August, Committee Member

Author:

Justice-bitner, Stephanie Lynn

Title:

An Investigation of Mu-Opioid Receptor Interacting Proteins Within the Mu-Opioid Receptor Signaling Complex

Graduate Program:

Genetics

Keywords:

mu-opioid receptor
ubiquitin
G-protein
kappa-opioid receptor
delta-opioid receptor
yeast two-hybrid
SIAH1
SIAH2

File:

Download Thesis_FINAL.pdf

Committee Members:

Robert G Levenson, Dissertation Advisor/Co-Advisor
Robert G Levenson, Committee Chair/Co-Chair
Victor J Ruiz Velasco, Committee Chair/Co-Chair
Laura Carrel, Committee Member
Vincent Chau, Committee Member

Author:

Alkhateeb, Ahmed Awni

Title:

The Role of Serum Ferritin in Breast Tumorigenesis: Implications for Cancer-associated Inflammation in Tumor Progression and Therapy Resistance

Graduate Program:

Cell and Molecular Biology

Keywords:

ferritin
iron
inflammation
cancer-associated inflammation
breast cancer

File:

Download Alkhateeb_Dissertation_Corrected_Final.pdf

Committee Members:

James Robert Connor, Dissertation Advisor/Co-Advisor
Gavin Peter Robertson, Committee Member
Laura Carrel, Committee Member
Robert Harold Bonneau, Special Member
Sang Yong Lee, Committee Member
Allan Lipton, Committee Member

Author:

Baptiste, Beverly Ann

Title:

Frameshift Mutagenesis: From Test Tubes to Tumor Cells

Graduate Program:

Genetics

Keywords:

DNA polymerase kappa
replication
mismatch repair
mutagenesis
microsatellite

File:

Download Baptiste_06182013.pdf

Committee Members:

Kristin Ann Eckert, Dissertation Advisor/Co-Advisor
Keith C Cheng, Committee Member
Neil David Christensen, Committee Member
Laura Carrel, Committee Chair/Co-Chair

Author:

Stahl, Jill

Title:

Genetic, Epigenetic and Chromosomal Domain Influences on Gene Expression from the Inactive X Chromosome

Graduate Program:

Genetics

Keywords:

X chromosome inactivation
X chromosome
gene expression
DNA methylation

File:

Download Stahl_Final_Revision_9-1-13.pdf

Committee Members:

Laura Carrel, Dissertation Advisor/Co-Advisor
Laura Carrel, Committee Chair/Co-Chair
Edward Joseph Gunther, Committee Member
Kristin Ann Eckert, Committee Member
Kent Eugene Vrana, Committee Member

Author:

Horvath, Lindsay Marie

Title:

Deletion of an X-inactivation boundary disrupts adjacent gene silencing

Graduate Program:

Genetics

Keywords:

X chromosome
gene expression
domain boundary
boundary regulation
X-chromosome inactivation

File:

Download HorvathThesisRevised2.pdf

Committee Members:

Laura Carrel, Dissertation Advisor/Co-Advisor
Sergei A Grigoryev, Committee Member
Jeffery Thomas Sample, Committee Member
David Joseph Spector, Committee Member

Author:

Berry, Gregory John

Title:

Mechanisms of insulin-dependent diabetes locus 9-mediated protection from type 1 diabetes

Graduate Program:

Microbiology and Immunology

Keywords:

Type 1 Diabetes
NOD mouse
Insulin-dependent diabetes locus 9
B cells

File:

Download GBerry_PhD_dissertation.pdf

Committee Members:

Hanspeter Waldner, Dissertation Advisor/Co-Advisor
Hanspeter Waldner, Committee Chair/Co-Chair
Laura Carrel, Committee Member
Todd Schell, Committee Member
Neil David Christensen, Committee Member
Jianxun Song, Committee Member
Laura Carrel, Special Member

Author:

Temple, Rachel Mary

Title:

Epstein-Barr virus infection and replication in stratified epithelial cells

Graduate Program:

Microbiology and Immunology

Keywords:

organotypic raft culture
stratified epithelium
Epstein-Barr virus
lytic replication

File:

Download Rachel_Temple_Thesis.pdf

Committee Members:

Clare E Sample, Dissertation Advisor/Co-Advisor
Clare E Sample, Committee Chair/Co-Chair
Craig Matthew Meyers, Committee Member
Todd Schell, Committee Member
Jeffery Thomas Sample, Committee Member
Laura Carrel, Committee Member

Author:

Young, Heather Marie

Title:

A potential role for long, non-coding RNAs in regulating escape domain boundaries on the inactive X chromosome

Graduate Program:

Biomedical Sciences

Keywords:

X inactivation
X chromosome
lncRNA
AK148627
Kdm5c
boundary regulation
escape domain

File:

Download HMYoung_Thesis_Final_Submission.pdf

Committee Members:

Laura Carrel, Thesis Advisor/Co-Advisor

Author:

Schubert, Michael Bruce

Title:

Role of linker DNA length and linker histone occupancy in chromatin compaction

Graduate Program:

Biochemistry and Molecular Biology

Keywords:

Chromatin
chromatin structure
nucleosome
linker histone
analytical ultracentrifugation
electron microscopy
EMANIC

File:

Download Schubert_Michael_-_BCHEM_Thesis.pdf

Committee Members:

Sergei A Grigoryev, Thesis Advisor/Co-Advisor
Laura Carrel, Thesis Advisor/Co-Advisor
Gregory Steven Yochum, Thesis Advisor/Co-Advisor

Author:

Rennoll, Sherri Ann

Title:

Transcriptional regulation of the c-MYC (MYC) proto-oncogene by oncogenic Wnt/β-catenin signaling in colorectal carcinomas

Graduate Program:

Cell and Molecular Biology

Keywords:

MYC
beta-catenin
AXIN2
colorectal cancer

File:

Download Rennoll_Dissertation_Final.pdf

Committee Members:

Gregory Yochum, Dissertation Advisor/Co-Advisor
Gregory Yochum, Committee Chair/Co-Chair
Laura Carrel, Committee Member
Sergei A Grigoryev, Committee Member
Lisa M Shantz, Committee Member

Author:

Wang, Luojun

Title:

The Joint Modeling of Recurrent Events and Other Failure Time Events

Graduate Program:

Biostatistics

Keywords:

survival analysis
joint modeling
semi-competing risks
recurrent events
acute kidney injury
tri-vairate Weibull
acute kidney injury
tri-variate Weibull

File:

Download Dissertation_LuojunWang.pdf

Committee Members:

Vernon Michael Chinchilli, Dissertation Advisor/Co-Advisor
Vernon Michael Chinchilli, Committee Chair/Co-Chair
David Theodore Mauger, Committee Member
Lan Kong, Committee Member
Laura Carrel, Outside Member

Author:

Bywaters Sylvester, Stephanie Marie

Title:

ANTI-CAPSID MONOCLONAL ANTIBODIES: TOOLS TO ASSESS HPV NEUTRALIZATION AND CAPSID STRUCTURE

Graduate Program:

Microbiology and Immunology

Keywords:

HPV
monoclonal antibody
capsid
structure
L2
competition

File:

Download Stephanie_Bywaters_Final_Thesis_June_5.pdf

Committee Members:

Neil David Christensen, Dissertation Advisor/Co-Advisor
Neil David Christensen, Committee Chair/Co-Chair
Craig Matthew Meyers, Committee Member
Susan Hafenstein, Committee Member
Laura Carrel, Outside Member
Rebecca C Craven, Committee Member

Author:

Lengel, Kathleen

Title:

ETHNIC-SPECIFIC HUMAN PAPILLOMAVIRUS TYPE-16 VARIANTS EXHIBIT DISTINCT MODES OF HOST ENTRY AND INFECTION

Graduate Program:

Biomedical Sciences

Keywords:

HPV
Virus entry

File:

Download KLengel_Thesis_2_2018.pdf

Committee Members:

Craig Matthew Meyers, Thesis Advisor/Co-Advisor
Neil David Christensen, Committee Member
Laura Carrel, Committee Member

Author:

Emrich, Scott

Title:

Insights into the Diversity of Calcium Signaling in B Lymphocytes

Graduate Program:

Biomedical Sciences (PHD)

Keywords:

Calcium signaling
Immunity
B lymphocyte
Store-operated Ca2+ entry

File:

Download Emrich_Thesis_2021_Final.pdf

Committee Members:

Neil Christensen, Major Field Member
Salvatore Stella, Major Field Member
Laura Carrel, Outside Unit & Field Member
Mohamed Trebak, Chair & Dissertation Advisor
Donald Gill, Major Field Member
Ralph Keil, Program Head/Chair

Author:

Sauteraud, Renan

Title:

Statistical Methods for the Functional Genomic Analysis of the X Chromosome

Graduate Program:

Biostatistics (PHD)

Keywords:

Biostatistics
X-Chromosome inactivation
Mixture models
Sex-biased diseases

File:

Download Penn_State_University_thesis___Renan.pdf

Committee Members:

Dajiang Liu, Chair & Dissertation Advisor
David Mauger, Major Field Member
Arthur Berg, Major Field Member
Nancy Olsen, Special Member
Arthur Berg, Program Head/Chair
Laura Carrel, Outside Field Member & Dissertation Advisor
Ziaur Rahman, Outside Unit Member

Author:

Moussa, Karine

Title:

X-Viz: Annotation and Visualization of Genes in the Human X-Chromosomes by their Activation States

Graduate Program:

Bioinformatics and Genomics (MS)

Keywords:

X chromosome inactivation
gene expression
sex-biased traits

File:

Download KM_MS_Thesis_2021.pdf

Committee Members:

Dajiang Liu, Thesis Advisor/Co-Advisor
Laura Carrel, Committee Member
George Perry, Program Head/Chair
Suzanne Gonzalez, Thesis Advisor/Co-Advisor

Author:

Cheng, Yuhuan

Title:

Trans-Ethnic Meta-Analysis on Lipid Exome Sequencing Data

Graduate Program:

Bioinformatics and Genomics

Keywords:

GWAS
trans-ethnic
meta-analysis
lipids
cardiovascular disease
rare variant
whole-exome sequence

File:

Download FinalThesis.pdf

Committee Members:

Dajiang Liu, Thesis Advisor/Co-Advisor
George H Perry, Program Head/Chair
Laura Carrel, Committee Member
Duanping Liao, Committee Member

Author:

Ingraham, Phoebe

Title:

Assessment of Sex-biased Phenotypic Patterns in Drosophila Homologs of Neurodevelopmental Disease-associated Genes

Graduate Program:

Molecular, Cellular, and Integrative Biosciences (MS)

Keywords:

Drosophila melanogaster
Sex-bias
Neurodevelopment
Genetics
Genetic interaction
CNVs
Genetic models
Neurodevelopmental disease

File:

Download Thesis_PMI_06.25.2021.pdf

Committee Members:

Melissa Rolls, Program Head/Chair
Santhosh Girirajan, Thesis Advisor/Co-Advisor
Stephen Wade Schaeffer, Committee Member
Laura Carrel, Committee Member

Author:

Khunsriraksakul, Chachrit

Title:

INTEGRATING GENOMIC, EPIGENOMIC, AND 3D GENOMIC DATA TO EMPOWER DISCOVERY, RISK PREDICTION, AND DRUG REPOSITIONING

Graduate Program:

Bioinformatics and Genomics (PhD)

Keywords:

Transcriptome-wide association studies
Genome-wide association studies
Systemic lupus erythematosus
Computational drug repurposing
Functional genomics
3D genomics
Epigenomics

File:

Login to Download

Committee Members:

Dajiang Liu, Chair & Dissertation Advisor
Qunhua Li, Major Field Member
Laura Carrel, Major Field Member
James Broach, Major Field Member
Aron Lukacher, Outside Unit & Field Member
Nancy Olsen, Special Member
George Perry, Program Head/Chair