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Author:

Costanzo, Alessandra

Title:

Regulation of the Extracytoplasmic Stress Factor Sigma E by the Alarmone ppGpp in Escherichia coli

Graduate Program:

Biochemistry, Microbiology, and Molecular Biology

Keywords:

sigma factor competition
Extracytoplasmic stress response
ppGpp

File:

Download ACostanzo-Dissertation.pdf

Committee Members:

Sarah Ellen Ades, Committee Chair/Co-Chair
Stephen John Knabel, Committee Member
Katsuhiko Murakami, Committee Member
B Tracy Nixon, Committee Member
Allen T Phillips, Committee Member

Author:

Missra, Anamika

Title:

BIOCHEMICAL ANALYSIS OF INTERACTIONS OF DSIF AND NELF WITH THE DROSOPHILA RNA POLYMERASE II TRANSCRIPTION ELONGATION COMPLEX

Graduate Program:

Biochemistry, Microbiology, and Molecular Biology

Keywords:

gene regulation
transcription
polymerase

File:

Download Anamika_Missra_Dissertation_Final.pdf

Committee Members:

David Scott Gilmour, Dissertation Advisor/Co-Advisor
David Scott Gilmour, Committee Chair/Co-Chair
Joseph C. Reese, Committee Member
Katsuhiko Murakami, Committee Member
Yanming Wang, Committee Member
Kyung An Han, Committee Member

Author:

Klein, Brianna Joy

Title:

CRYSTAL STRUCTURE AND BIOCHEMICAL ANALYSIS OF ARCHAEAL RNA POLYMERASE TRANSCRIPTION ELONGATION FACTORS

Graduate Program:

Biochemistry, Microbiology, and Molecular Biology

Keywords:

RNA-directed RNA synthesis by DNA-dependent aRNAP
Pyrococcus furiosus Spt4/5
Structure of Spt4/5 at 1.8 Å
Archaeal RNAP
Inhibited TECs With or Without TFS

File:

Download BjK_dissertation_2010.pdf

Committee Members:

Katsuhiko Murakami, Dissertation Advisor/Co-Advisor
Katsuhiko Murakami, Committee Chair/Co-Chair
Paul Lee Babitzke, Committee Member
David Scott Gilmour, Committee Member
B Tracy Nixon, Committee Member
Biao He, Committee Member

Author:

Reichlen, Matthew James

Title:

Functional Assessment of Transcriptional Regulation in the Methanogen, Methanosarcina acetivorans

Graduate Program:

Biochemistry, Microbiology, and Molecular Biology

Keywords:

Archaea
Transcription
Methanogen
Methanosarcina
acetivorans

File:

Download Final_thesis_revised.pdf

Committee Members:

James Gregory Ferry, Dissertation Advisor/Co-Advisor
James Gregory Ferry, Committee Chair/Co-Chair
Katsuhiko Murakami, Committee Chair/Co-Chair
Sarah Ellen Ades, Committee Member
Benjamin Franklin Pugh, Committee Member
Philip C. Bevilacqua, Committee Member

Author:

Gleghorn, Michael L

Title:

X-RAY CRYSTAL STRUCTURES EXPLAIN DNA-HAIRPIN PROMOTER BINDING AND DE NOVO TRANSCRIPTION INITIATION FOR THE N4 VIRION RNA POLYMERASE

Graduate Program:

Biochemistry, Microbiology, and Molecular Biology

Keywords:

X-ray crystallography
RNA polymerase
transcription
de novo transcription initiation
two-metal catalysis

File:

Download Gleghorn_2008_Final_Dissertation.pdf

Committee Members:

Katsuhiko Murakami, Committee Chair/Co-Chair
Biao He, Committee Member
Craig Eugene Cameron, Committee Member
B Tracy Nixon, Committee Member
Song Tan, Committee Member

Author:

Romberger, Steven Paul

Title:

STRUCTURE-FUNCTION STUDIES OF HOMODIMERIC TYPE I REACTION CENTERS FROM AN ANAEROBIC AND AN AEROBIC BACTERIUM

Graduate Program:

Biochemistry, Microbiology, and Molecular Biology

Keywords:

photosynthesis
phototrophy
heliobacteria
Chloracidobacterium thermophilum
type I reaction center
iron-sulfur cluster

File:

Download romberger2011dissertation.pdf

Committee Members:

John H Golbeck, Dissertation Advisor/Co-Advisor
John H Golbeck, Committee Chair/Co-Chair
Donald Ashley Bryant, Committee Chair/Co-Chair
Sarah Ellen Ades, Committee Member
Katsuhiko Murakami, Committee Member
Wayne Roger Curtis, Committee Member

Author:

Gopalkrishnan, Saumya

Title:

Regulation of the alternative sigma factor,σE, during nutrient limitation in Escherichia coli

Graduate Program:

Biochemistry, Microbiology, and Molecular Biology

Keywords:

sigmaE
ppGpp
starvation
transcription
Escherichia coli

File:

Download Gopalkrishnan_S_Thesis.pdf

Committee Members:

Sarah Ellen Ades, Dissertation Advisor/Co-Advisor
Paul Lee Babitzke, Committee Member
B Tracy Nixon, Committee Member
Katsuhiko Murakami, Committee Member
Edward G Dudley, Special Member
Sarah Ellen Ades, Committee Chair/Co-Chair

Author:

Ramadoss, Nitya S

Title:

The trans-translation pathway as a target for broad-spectrum antibacterial development

Graduate Program:

Biochemistry, Microbiology, and Molecular Biology

Keywords:

trans-translation
tmRNA
antibiotic development
small molecules
Shigella flexneri

File:

Download ramadoss_dissertation.pdf

Committee Members:

Kenneth Charles Keiler, Dissertation Advisor/Co-Advisor
Kenneth Charles Keiler, Committee Chair/Co-Chair
Sarah Ellen Ades, Committee Member
Squire J Booker, Committee Member
Katsuhiko Murakami, Committee Member
Edward G Dudley, Committee Member

Author:

Basu, Ritwika

Title:

Mechanistic investigations of nucleotidyl-transfer reaction and de novo initiation in Rna polymerases by X-ray crystallography

Graduate Program:

Biochemistry, Microbiology, and Molecular Biology

Keywords:

soak-trigger freeze X-ray crystallography
nucleotidyl-transfer reaction
RNA polymerase
N4 bacteriophage
Thermus thermophilus

File:

Download Final_Dissertation.pdf

Committee Members:

Katsuhiko Murakami, Dissertation Advisor/Co-Advisor
Katsuhiko Murakami, Committee Chair/Co-Chair
Craig Eugene Cameron, Committee Member
Paul Lee Babitzke, Committee Member
Andrey S Krasilnikov, Committee Member
Scott A Showalter, Committee Member

Author:

El-mowafi, Shaima

Title:

Development and Validation of Screens For Drugs targeting Gram-negative Bacteria

Graduate Program:

Biochemistry, Microbiology, and Molecular Biology

Keywords:

Gram-negative pathogens
virulence
σE-sRNA-Hfq pathway
cyclic peptides

File:

Download thesis_Shaima_El-mowafi.pdf

Committee Members:

Kenneth Charles Keiler, Dissertation Advisor/Co-Advisor
Sarah Ellen Ades, Committee Member
Katsuhiko Murakami, Committee Member
Squire J Booker, Committee Member
Michael Axtell, Committee Member