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Start Over Graduate Program Bioengineering (PHD)

1. The Role of NRF2 in Collective Cancer Invasion

open_access
Open Access
Author:
Vilchez Mercedes, Samuel
Title:
The Role of NRF2 in Collective Cancer Invasion
Graduate Program:
Bioengineering (PHD)
Keywords:
Hybrid E/M
Cancer
Bladder Cancer
Notch signaling
Leader cells
EMT
Collective Migration
NRF2
File:
Download SV_Dissertation_final_noBoxes.pdf
Committee Members:
Peter Butler, Major Field Member
Yong Wang, Major Field Member
Zhi-Chun Lai, Outside Unit & Field Member
Daniel Hayes, Program Head/Chair
Pak Kin Wong, Chair & Dissertation Advisor

2. Intelligent Ultrasound and Photoacoustic Imaging Systems: Design, Development and Beyond

open_access
Open Access
Author:
Agrawal, Sumit
Title:
Intelligent Ultrasound and Photoacoustic Imaging Systems: Design, Development and Beyond
Graduate Program:
Bioengineering (PHD)
Keywords:
ultrasound imaging
photoacoustic imaging
artificial intelligence
spectral unmixing
artifact removal
low-cost devices
portable medical imaging device
File:
Download PhD_Thesis_Sumit_Agrawal.pdf
Committee Members:
Sri-Rajasekhar Kothapalli, Chair & Dissertation Advisor
William Higgins, Major Field Member
Nanyin Zhang, Major Field Member
Vishal Monga, Outside Unit & Field Member
Daniel Hayes, Program Head/Chair

3. Development of a Biomimetic Extracellular Matrix Using Aptamers and Hydrogels

open_access
Open Access
Author:
Abune, Lidya
Title:
Development of a Biomimetic Extracellular Matrix Using Aptamers and Hydrogels
Graduate Program:
Bioengineering (PHD)
Keywords:
Aptamer
Biomimetic extracellular matrix
Hydrogel
Protein release
Cell attachment
File:
Download Dissertation-Lidya-Abune-2022.pdf
Committee Members:
Peter Butler, Major Field Member
Yong Wang, Chair & Dissertation Advisor
Jian Yang, Major Field Member
Daniel Hayes, Program Head/Chair
Ralph Colby, Outside Unit & Field Member

4. EXPLOITING THE FLUOROUS EFFECT TO CREATE SUPRAMOLECULAR FLUOROPEPTIDE MATERIALS

open_access
Open Access
Author:
Sloand, Janna
Title:
EXPLOITING THE FLUOROUS EFFECT TO CREATE SUPRAMOLECULAR FLUOROPEPTIDE MATERIALS
Graduate Program:
Bioengineering (PHD)
Keywords:
Fluorous Effect
Perfluorocarbons
Peptides
Self-Assembly
Templated Assembly
Protein Delivery
Ultrasound
File:
Download Janna_Sloand_-_PhD_-_Dissertation_v6.pdf
Committee Members:
William Hancock, Major Field Member
Justin Brown, Major Field Member
Scott Medina, Chair & Dissertation Advisor
Daniel Hayes, Major Field Member
Julianna Simon, Outside Unit & Field Member
Daniel Hayes, Program Head/Chair

5. Mechanical response of tendons to common therapies and the effects of tendon injury progression

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Restricted (Penn State Only)
Author:
Khandare, Sujata
Title:
Mechanical response of tendons to common therapies and the effects of tendon injury progression
Graduate Program:
Bioengineering (PHD)
Keywords:
Dry needling
Focused ultrasound
Tendon
Mechanical properties
Mechanical testing
Rotator cuff
Computational model
Glenohumeral joint
Muscle activation
Force couple
Tear severity
Rotator cuff tear
File:
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Committee Members:
Stephen Piazza, Outside Unit & Field Member
Spencer Szczesny, Major Field Member
Meghan Vidt, Chair & Dissertation Advisor
Julianna Simon, Major Field Member
Daniel Hayes, Program Head/Chair

6. Nanoparticle-Enhanced Drug Delivery: Delivering Small Nucleic Acid Therapeutics to Combat Disease at the Gene Expression Level

restricted
Restricted
Author:
Alden, Nicholas
Title:
Nanoparticle-Enhanced Drug Delivery: Delivering Small Nucleic Acid Therapeutics to Combat Disease at the Gene Expression Level
Graduate Program:
Bioengineering (PHD)
Keywords:
Plasmonic Nanoparticles
Near-Infrared
Diels-Alder
Synthetic miRNA Mimics
Head & Neck Cancer
Lung Cancer
Poly-Beta(Amino Esters)
Nanoparticles
Drug Delivery Systems
File:

No files available due to restrictions.

Committee Members:
Daniel Hayes, Program Head/Chair
Adam Glick, Outside Unit & Field Member
Pak Kin Wong, Major Field Member
Yong Wang, Major Field Member
Scott Medina, Major Field Member
Daniel Hayes, Chair & Dissertation Advisor

7. Investigating the bioeffects of perfluoroalkyls towards advanced image-guided protein delivery technologies

restricted
Restricted
Author:
Lawanprasert, Atip
Title:
Investigating the bioeffects of perfluoroalkyls towards advanced image-guided protein delivery technologies
Graduate Program:
Bioengineering (PHD)
Keywords:
Drug Delivery
Fluorine
Ultrasound
Protein
File:

No files available due to restrictions.

Committee Members:
Scott Medina, Chair & Dissertation Advisor
Daniel Hayes, Major Field Member
Daniel Hayes, Program Head/Chair
William Hancock, Major Field Member
Joseph Cotruvo, Outside Unit & Field Member

8. Development and Evaluation of DNA Nanostructures for Cell Surface Engineering

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Restricted (Penn State Only)
Author:
Davis, Brandon
Title:
Development and Evaluation of DNA Nanostructures for Cell Surface Engineering
Graduate Program:
Bioengineering (PHD)
Keywords:
cell surface engineering
DNA nanotechnology
nongenetic cell engineering
File:
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Committee Members:
Yong Wang, Chair & Dissertation Advisor
Xiaojun Lian, Major Field Member
Scott Medina, Major Field Member
Yuguo Lei, Professor in Charge/Director of Graduate Studies
Hong Zheng, Outside Unit & Field Member

9. Evaluation of Accelerated Wear Tester Fluid Mechanics on Transcatheter Aortic Valve Motion

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Restricted (Penn State Only)
Author:
Ponnaluri, Sailahari Venkatasri
Title:
Evaluation of Accelerated Wear Tester Fluid Mechanics on Transcatheter Aortic Valve Motion
Graduate Program:
Bioengineering (PHD)
Keywords:
Accelerated Wear Tester
Transcatheter Heart Valves
Particle Image Velocimetry
File:
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Committee Members:
Peter Butler, Major Field Member
Keefe Manning, Chair & Dissertation Advisor
Robert Campbell, Outside Unit & Field Member
Francesco Costanzo, Major Field Member
Daniel Hayes, Program Head/Chair

10. Tissue Engineering Strategies for Regeneration of the Tendon-Bone Interface

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Restricted (Penn State Only)
Author:
Berntsen, Lisa
Title:
Tissue Engineering Strategies for Regeneration of the Tendon-Bone Interface
Graduate Program:
Bioengineering (PHD)
Keywords:
Mesenchymal Stem Cells
Tissue Engineering
Tendon
Bone
Enthesis
miRNA
Osteogenesis
Cell Sheets
File:
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Committee Members:
Justin Brown, Major Field Member
Xiaojun Lian, Major Field Member
Jian Yang, Major Field Member
Daniel Hayes, Chair & Dissertation Advisor
Daniel Hayes, Program Head/Chair
Julianna Simon, Outside Unit & Field Member

11. Forecasting and Forward Engineering Anticancer Drug Resistance

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Restricted (Penn State Only)
Author:
Leighow, Scott
Title:
Forecasting and Forward Engineering Anticancer Drug Resistance
Graduate Program:
Bioengineering (PHD)
Keywords:
cancer
drug resistance
systems biology
synthetic biology
stochastic modeling
gene therapy
File:
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Committee Members:
David Kennedy, Outside Unit & Field Member
Xiaojun Lian, Major Field Member
Justin Pritchard, Chair & Dissertation Advisor
Daniel Hayes, Program Head/Chair
William Hancock, Major Field Member

13. INVESTIGATE THE ROLE OF GLOBAL BRAIN ACTIVITY IN NEURODEGENERATION AND AGING

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Restricted (Penn State Only)
Author:
Han, Feng
Title:
INVESTIGATE THE ROLE OF GLOBAL BRAIN ACTIVITY IN NEURODEGENERATION AND AGING
Graduate Program:
Bioengineering (PHD)
Keywords:
Resting-state functional magnetic resonance imaging
global brain activity
global signal
glymphatic system
amyloid-β
cross-hierarchy difference
Alzheimer's disease
cerebrospinal fluid
Parkinson’s disease
healthy aging
the coupling between the global brain and the cerebrospinal fluid fMRI signals
File:
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Committee Members:
Xiao Liu, Chair & Dissertation Advisor
Nanyin Zhang, Major Field Member
Michele Diaz, Major Field Member
Daniel Hayes, Program Head/Chair
Xuemei Huang, Outside Unit & Field Member
Xiang Zhang, Outside Field Member

14. Neuronal correlates of the BOLD signal during visual stimulations

open_access
Open Access
Author:
Zhang, Qingqing
Title:
Neuronal correlates of the BOLD signal during visual stimulations
Graduate Program:
Bioengineering (PHD)
Keywords:
Unanesthetized rat fMRI
visual stimulation
BOLD signal
neuronal signal
File:
Download PhD_Dissertation__Qingqing_Zhang.pdf
Committee Members:
Patrick Drew, Major Field Member
Bruce Gluckman, Major Field Member
Xiao Liu, Major Field Member
Nanyin Zhang, Chair & Dissertation Advisor
Thomas Neuberger, Outside Unit & Field Member
Daniel Hayes, Program Head/Chair

15. Structure-Function Changes in Late Stages of Tendon Development and its Sensitivity to Musculoskeletal Activity

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Restricted (Penn State Only)
Author:
Peterson, Benjamin
Title:
Structure-Function Changes in Late Stages of Tendon Development and its Sensitivity to Musculoskeletal Activity
Graduate Program:
Bioengineering (PHD)
Keywords:
Tendon
Tendon Development
Multiscale Mechanics
File:
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Committee Members:
Esther Gomez, Major Field Member
Claire Thomas, Outside Unit & Field Member
Spencer Szczesny, Chair & Dissertation Advisor
Paula Murphy, Special Member
Gregory Lewis, Major Field Member
Daniel Hayes, Program Head/Chair

16. Drivers of fatigue induced degeneration in a mouse Achilles tendon explant model

open_access
Open Access
Author:
Pedaprolu, Krishna
Title:
Drivers of fatigue induced degeneration in a mouse Achilles tendon explant model
Graduate Program:
Bioengineering (PHD)
Keywords:
tendon
biomechanics
degeneration
tendinopathy
bioreactor
explant
Achilles tendon
File:
Download Final_Thesis_Krishna_Pedaprolu.pdf
Committee Members:
Esther Gomez, Major Field Member
Justin Brown, Major Field Member
Spencer Szczesny, Chair & Dissertation Advisor
Jonas Rubenson, Outside Unit & Field Member
Kathleen Derwin, Special Member
Daniel Hayes, Program Head/Chair

17. The development of photoactivated nanoparticles for therapeutic miRNA delivery to selectively induce apoptosis in cancer cells

restricted_to_institution
Restricted (Penn State Only)
Author:
Liu, Yiming
Title:
The development of photoactivated nanoparticles for therapeutic miRNA delivery to selectively induce apoptosis in cancer cells
Graduate Program:
Bioengineering (PHD)
Keywords:
microRNAs
retro-Diels-Alder
Immunomodulation
Nanoparticle
Cancer therapy
File:
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Committee Members:
Adam Glick, Outside Unit & Field Member
Pak Kin Wong, Major Field Member
Jian Yang, Major Field Member
Daniel Hayes, Chair & Dissertation Advisor
Daniel Hayes, Program Head/Chair

18. Molecular Mechanisms of Microtubule Assembly

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Restricted (Penn State Only)
Author:
Cleary, Joseph
Title:
Molecular Mechanisms of Microtubule Assembly
Graduate Program:
Bioengineering (PHD)
Keywords:
Microtubule
Biophysics
Kinetics
Assembly
File:
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Committee Members:
William Hancock, Chair & Dissertation Advisor
Melissa Rolls, Outside Unit & Field Member
Pak Kin Wong, Major Field Member
Igor Aronson, Major Field Member
Daniel Hayes, Program Head/Chair
Justin R Pritchard, Special Signatory

19. Acoustic and magnetic control of synthetic and biological microswimmers

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Restricted (Penn State Only)
Author:
Dominguez Rubio, Leonardo
Title:
Acoustic and magnetic control of synthetic and biological microswimmers
Graduate Program:
Bioengineering (PHD)
Keywords:
Active matter
Acoustics
Ferrofluids
Microfluidics
Nanoparticles
File:
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Committee Members:
William Hancock, Major Field Member
Justin Brown, Major Field Member
Pak Kin Wong, Major Field Member
Igor Aronson, Chair & Dissertation Advisor
Ayusman Sen, Outside Unit & Field Member
Daniel Hayes, Program Head/Chair

20. Application of human pluripotent stem cells and genetic engineering to treating and modeling pancreatic and cardiovascular degenerative diseases

open_access
Open Access
Author:
Jiang, Yuqian
Title:
Application of human pluripotent stem cells and genetic engineering to treating and modeling pancreatic and cardiovascular degenerative diseases
Graduate Program:
Bioengineering (PHD)
Keywords:
Human pluripotent stem cells
CRISPR
Gene editing
RNA editing
Pancreatic differentiation
cardiomyocyte characterization
Nucleic acid detection
File:
Download Dissertation_Yuqian_Jiang_final.pdf
Committee Members:
Xiaojun Lian, Chair & Dissertation Advisor
Daniel Hayes, Major Field Member
Daniel Hayes, Program Head/Chair
Jian Yang, Major Field Member
Weihua Guan, Outside Unit & Field Member

21. Personalized Intravesical Immunotherapy for Bladder Cancer

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Restricted (Penn State Only)
Author:
Yan, Yue
Title:
Personalized Intravesical Immunotherapy for Bladder Cancer
Graduate Program:
Bioengineering (PHD)
Keywords:
cancer
bladder cancer
immunotherapy
cancer immunotherapy
personalized medicine
File:
Login to Download
Committee Members:
Daniel Hayes, Program Head/Chair
David Degraff, Outside Unit & Field Member
Pak Kin Wong, Chair & Dissertation Advisor
Yong Wang, Major Field Member
Justin Pritchard, Major Field Member
Yuguo Lei, Major Field Member

22. Development of Citrate – Based Biomaterials for Orthopedic Tissue Regeneration and Ocular Drug Delivery

restricted
Restricted
Author:
Gerhard, Ethan M
Title:
Development of Citrate – Based Biomaterials for Orthopedic Tissue Regeneration and Ocular Drug Delivery
Graduate Program:
Bioengineering (PHD)
Keywords:
citrate
citric acid
biomaterials
ophthamology
fluorescent biomaterials
ocular biomaterials
metabonegenesis
orthopedic biomaterials
File:

No files available due to restrictions.

Committee Members:
Xiaojun Lian, Major Field Member
Daniel Hayes, Program Head/Chair
Zhiwen Liu, Outside Unit & Field Member
Sulin Zhang, Major Field Member
Yong Wang, Chair & Dissertation Advisor
Jian Yang, Special Member

23. Nanomaterial-Integrated Devices, Systems, and Platforms for Extracellular Vesicle Enrichment and Clinical Applications

open_access
Open Access
Author:
Ditty, Mackenzie
Title:
Nanomaterial-Integrated Devices, Systems, and Platforms for Extracellular Vesicle Enrichment and Clinical Applications
Graduate Program:
Bioengineering (PHD)
Keywords:
extracellular vesicles
carbon nantoubes
lipid nanoprobes
devices
nanomaterials
File:
Download M.Maurer_Ditty_Dissertation_FINAL_v2.pdf
Committee Members:
Daniel Hayes, Program Head/Chair
Zhiwen Liu, Outside Unit Member
Jian Yang, Major Field Member
Justin Pritchard, Chair & Dissertation Advisor
Weihua Guan, Outside Field Member

24. Investigating the role of brain arousal fluctuations in resting-state functional magnetic resonance imaging

open_access
Open Access
Author:
Gu, Yameng
Title:
Investigating the role of brain arousal fluctuations in resting-state functional magnetic resonance imaging
Graduate Program:
Bioengineering (PHD)
Keywords:
resting-state fMRI
arousal modulations
functional connectivity
head motion
cortical hierarchy
infra-slow propagating activity
multimodal neuroimaging
global signal
autonomic activity
File:
Download Dissertation-Yameng-Gu-final.pdf
Committee Members:
Patrick Drew, Major Field Member
Rick Gilmore, Outside Unit & Field Member
Xiao Liu, Chair & Dissertation Advisor
Nanyin Zhang, Major Field Member
Daniel Hayes, Program Head/Chair

25. Artificial Receptor Display for Cell Surface Engineering

open_access
Open Access
Author:
Wang, Xuelin
Title:
Artificial Receptor Display for Cell Surface Engineering
Graduate Program:
Bioengineering (PHD)
Keywords:
Cell surface engineering
Cell recognition
polyvalency
Aptamer
File:
Download Xuelin_Wang_Dissertation_Final.pdf
Committee Members:
Daniel Hayes, Program Head/Chair
Yuguo Lei, Major Field Member
Yong Wang, Chair & Dissertation Advisor
Xiaojun Lian, Major Field Member
Girish Kirimanjeswara, Outside Unit & Field Member
Justin Pritchard, Major Field Member

26. Understanding the nature and drivers of brain motion in a behaving mouse model

open_access
Open Access
Author:
Garborg, Christopher
Title:
Understanding the nature and drivers of brain motion in a behaving mouse model
Graduate Program:
Bioengineering (PHD)
Keywords:
Brain Motion
Two-photon Microscopy
Intra-abdominal Pressure
Cerebrospinal Fluid
File:
Download Garborg_Dissertation_Final_20240317.pdf
Committee Members:
Patrick Drew, Chair & Dissertation Advisor
Spencer Szczesny, Major Field Member
Jean-Michel Mongeau, Outside Unit & Field Member
Sri-Rajasekhar Kothapalli, Major Field Member
Nanyin Zhang, Major Field Member
Yuguo Lei, Professor in Charge/Director of Graduate Studies

27. Microbial Profiling via Multimodal Single Cell Biosensors

open_access
Open Access
Author:
Lee, Jyong Huei
Title:
Microbial Profiling via Multimodal Single Cell Biosensors
Graduate Program:
Bioengineering (PHD)
Keywords:
Biosensors
Single Cell
Microbial Profiling
File:
Download Gary_Thesis_Final.pdf
Committee Members:
Yuguo Lei, Professor in Charge/Director of Graduate Studies
Pak Kin Wong, Chair & Dissertation Advisor
Scott Medina, Major Field Member
Justin Pritchard, Major Field Member
Nanyin Zhang, Major Field Member
Darrell Cockburn, Outside Unit & Field Member

28. The development of population-specific models to improve rehabilitation for shoulder injuries

restricted_to_institution
Restricted (Penn State Only)
Author:
Pataky, Joshua
Title:
The development of population-specific models to improve rehabilitation for shoulder injuries
Graduate Program:
Bioengineering (PHD)
Keywords:
Rotator cuff
Shoulder joint
Biomechanical phenomena
Computer simulation
Shoulder pain
Breast cancer survivors
Scapular kinematics
File:
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Committee Members:
Daniel Hayes, Program Head/Chair
Gregory Lewis, Outside Field Member
Stephen Piazza, Outside Unit & Field Member
Meghan Vidt, Chair & Dissertation Advisor
Sri-Rajasekhar Kothapalli, Major Field Member