Biodegradable Polyphosphazenes

Open Access
Nguyen, Nhu Quynh
Graduate Program:
Master of Science
Document Type:
Master Thesis
Date of Defense:
June 27, 2008
Committee Members:
  • Harry R Allcock, Thesis Advisor
  • biodegradable
  • polyphophazenes
This thesis focuses on the recent investigation of biodegradable polyphosphazenes to be utilized in biomedical application. Chapter 1 provides an overview of phosphazene chemistry and describes previous work on biodegradable polyphosphazenes. Chapter 2 describes the synthesis and characterization of aspartic acid, glutamic acid, serine and threonine containing polyphosphazenes. Chapter 3 addresses fundamental phosphazene chemistry by exploring the reactivity and hydrolytic behavior of the amide linkage on the phosphazene backbone. Synthesis and characterization using acetamide and benzamide side groups on the cyclic and polymeric phosphazenes were performed. The initial results revealed that the benzamide side group imparts hydrolytic instability to polyphosphazene. Chapter 4 investigates novel properties of poly(diethoxyphosphazene) as a potential candidate as surgical adhesive and in tissue engineering. This elastomer has a water contact angle of 62.1º, and degrades in aqueous media at different pH conditions. Finally, Chapter 5 examines the surface modification of poly[bis(trifluoroethoxy)phosphazene) with sodium ethoxide nucleophile. A model reaction in solution was performed to determine the extent of the reactivity of the side group exchange reaction.