INTEGRATED CHEMICAL AND BIOLOGICAL SYSTEMS IN NANOWIRE STRUCTURES TOWARDS NANO-SCALE SENSORS
Open Access
Author:
HERNANDEZ, ROSE MARIE
Graduate Program:
Materials
Degree:
Doctor of Philosophy
Document Type:
Dissertation
Date of Defense:
October 10, 2005
Committee Members:
Thomas E Mallouk, Committee Chair/Co-Chair William Blaine White, Committee Member James Hansell Adair, Committee Member Paul S Weiss, Committee Member Albert Eliot Segall, Committee Member
Nanowires composed of metal and conducting polymers with integrated proteins and chemical systems have been investigated as building blocks for next-generation nano-scale sensors and assemblies. These nanowires were fabricated by combining chemical and electrochemical methods of synthesis of gold and conducting polymers in nanopores of anodized alumina membranes. Polymer nanowires were synthesized from buffer solutions as a mean to promote a biocompatible environment for the incorporation of proteins. A variety of proteins were incorporated into the polymer matrix by entrapment during polymerization that imparted the polymer material with biological functionality. Another class of composite nanowires containing electro-active conducting polymer junctions was developed for applications in chemical sensor arrays. The methodologies described in this thesis provide an inexpensive and straightforward approach to the synthesis of anisotropic nanoparticles incorporating a variety of biological and inorganic species that can be integrated to current microelectronic technologies for the development of nano-scale sensor arrays.
