ER QUALITY CONTROL OF PROTEIN FOLDING

Open Access
Author:
Kim, Woong
Graduate Program:
Biochemistry, Microbiology, and Molecular Biology
Degree:
Doctor of Philosophy
Document Type:
Dissertation
Date of Defense:
April 18, 2005
Committee Members:
  • Wesley Tsoekjen Ng, Committee Chair
  • David Scott Gilmour, Committee Member
  • John H Golbeck, Committee Member
  • B Tracy Nixon, Committee Member
  • Kyung An Han, Committee Member
Keywords:
  • ERQC
  • ERAD
  • misfolded proteins
Abstract:
Endoplasmic Reticulum maintains a quality control mechanism that monitors the biogenesis of secretory proteins. Through this mechanism, properly folded proteins are transported to their appropriate destinations whereas misfolded proteins are recognized and targeted for degradation by ER Associated Protein Degradation machinery (ERAD). The factors and mechanisms that govern the recognition and targeting of misfolded proteins by the ERAD machinery are poorly understood. This thesis discusses the contribution we have made toward identifying the factors and elucidating the mechanisms that underlie ERAD machinery.