Molecular Tubes as Receptors for Biological Analytes
Open Access
Author:
Shorthill, Berkeley Jason
Graduate Program:
Chemistry
Degree:
Doctor of Philosophy
Document Type:
Dissertation
Date of Defense:
July 02, 2004
Committee Members:
Timothy E Glass, Committee Chair/Co-Chair A Daniel Jones, Committee Chair/Co-Chair Alan James Benesi, Committee Member Thomas E Mallouk, Committee Member Ming Tien, Committee Member
The design, synthesis, and binding properties of novel molecular tubes based on naphthalene subunits are described. Initial investigations produced 3,5- and 3,6-linked calix[n]naphthalenes, while subsequent endeavors resulted in the creation of functional chemosensors for fatty acid recognition in aqueous solution. One such chemosensor was found to be capable of selective recognition of lipids based solely on the shape of their hydrophobic surface. Brief overviews of shape selective recognition and calixarene chemistry are also presented.
