We are developing a novel drug delivery system that utilizes solid PVA (polyvinyl alcohol), a kind of biodegradable polymer with more mechanical strength to fabricate dissolving microneedles in combination with a LIG-based glucose sensor and a chemical heat source to revolutionize the way drugs are delivered to patients with diabetes and other conditions requiring glucose monitoring and drug therapy. Our study demonstrates the successful fabrication of PVA microneedles with excellent mechanical properties and the potential for use in biomedical applications. Additionally, the use of LIG glucose sensors in combination with silver nanoparticles and graphene oxide shows promising results for detecting glucose levels. The chemical heat source utilizes oxidation-reduction reactions to replace traditional electrical heating, potentially lowering the cost and making microneedle usage disposable and more convenient. This system combines the advantages of microneedles drug delivery with the added benefit of LIG glucose sensor detection, allowing for non-invasive glucose monitoring and optimal drug delivery. Future work can focus on optimizing the performance and functionality of the PVA microneedles and LIG glucose sensors to improve their practicality and usability in clinical settings.