Particle Image Velocimetry Measurements of Flow in an Anatomically-accurate Scaled Model of the Rodent Nasal Cavity

Open Access
Rumple, Christopher Ryan
Graduate Program:
Aerospace Engineering
Master of Science
Document Type:
Master Thesis
Date of Defense:
November 24, 2013
Committee Members:
  • Dennis K Mclaughlin, Thesis Advisor/Co-Advisor
  • Brent Craven, Thesis Advisor/Co-Advisor
  • Michael H Krane, Thesis Advisor/Co-Advisor
  • Particle Image Velocimetry
  • Internal Flow
  • Rodent Nasal Cavity
The mammalian nose is a multi-purpose organ that houses a convoluted airway labyrinth responsible for respiratory air conditioning, filtering of environmental contaminants, and chemical sensing. Because of the complexity of the nasal cavity, the anatomy and function of these upper airways remain poorly understood in most mammals. However, recent advances in high-resolution medical imaging, computational modeling, and experimental flow measurement techniques are now permitting the study of respiratory airflow and olfactory transport phenomena in anatomically-accurate reconstructions of the nasal cavity. Here, we focus on efforts to fabricate an anatomically-accurate transparent model for planar particle image velocimetry (PIV) measurements. Challenges in the design and fabrication of an optically transparent anatomical model with refractive index-matched working fluid are addressed. PIV velocity field measurements and resistance curve measurements are presented, which will later be used to validate concurrent computational fluid dynamics (CFD) simulations of mammalian nasal airflow.