Design and Applications of an Autoinductive, Chemical Amplification Reagent

Open Access
Baker, Matthew S
Graduate Program:
Doctor of Philosophy
Document Type:
Date of Defense:
June 06, 2014
Committee Members:
  • Scott T Phillips, Dissertation Advisor
  • Ayusman Sen, Committee Member
  • John V Badding, Committee Member
  • Michael Anthony Hickner, Special Member
  • Chemical Amplification
  • Autoinductive
  • Stimuli-Responsive
Synthetic reagents that are capable of exponentially amplifying a readout in response to a chemical or physical signal are a new strategy for achieving chemical amplification. Chemical amplification has been applied to a variety of fields including materials science, biology, and medicine. However, examples of synthetic exponential amplification systems have been limited in applications as a result of structural and synthetic complexity, environmental instability, and multicomponent requirements. This thesis describes the design of an autoinductive, exponential chemical amplification reagent and its applications to diagnostics and smart materials.