Palladium-catalyzed Halogenation Of Ortho-c-h Bonds Of Benzylamine Picolinamides And Arylethylamine Picolinamides
Open Access
Author:
Lu, Chengxi
Graduate Program:
Chemistry
Degree:
Master of Science
Document Type:
Master Thesis
Date of Defense:
August 13, 2012
Committee Members:
Gong Chen, Thesis Advisor/Co-Advisor Scott Trent Feldman, Thesis Advisor/Co-Advisor
Keywords:
Pd-catalyzed C-H activation Halogenation
Abstract:
A new Pd-catalyzed picolinamide-directed halogenation reaction of ortho-C(sp2)-H bonds is discussed. The usage of inexpensive inorganic salt (KBrO3, NaClO3/NaClO2 and KIO3) as halide source and K2S2O8 as oxidant offer a more practical method to introduce halide atoms onto aromatic organic compound. This method is effective on benzylamine picolinamides and arylethylamine picolinamides.
