Syntheses And Characterization Of Citrate-Based Biodegradable Materials And Their Applications

open_access
Open Access
Author:
Li, Qiyao
Graduate Program:
Bioengineering
Degree:
Doctor of Philosophy
Document Type:
Dissertation
Date of Defense:
June 04, 2020
Committee Members:
Jian Yang, Dissertation Advisor/Co-Advisor
Jian Yang, Committee Chair/Co-Chair
Nanyin Zhang, Committee Member
Pak Kin Wong, Committee Member
Qing Wang, Outside Member
Daniel J Hayes, Program Head/Chair
Keywords:
biomaterial
citric acid
polymer
Abstract:
Bioactive polymeric materials with the capability of regulating cell differentiation, adhesion, and migration hold great potential for many tissue engineering applications, such as bone and nerve regeneration, drug delivery, and so on. Additionally, polymeric materials gained popularity in agriculture, food, and construction industry due to their easily tunable mechanical and degradation properties achieved by manipulating polymerization conditions, composites formulation, and processing techniques. As needs across the engineering field have evolved and require increasingly sophisticated solutions, citrate-based biomaterials provide unique physical, chemical, and biological properties that can be customized to meet the complicated and specific requirements of regenerative engineering and other biomedical applications. We researched and investigated the citrate-based polymeric materials’ degradation behavior and mechanism, development of a new class of osteopromotive citrate-based materials with glycerophosphate salts for bone tissue engineering applications, and utilization of citrate-based resin in vegetable oil filtration. This scientific work aims to develop a variety of versatile citrate-based polymers and explore and demonstrate their applications in biomedical and vegetable oil purification fields.