Association between serum 25-Hydroxyvitamin D and Human Papillomavirus infection among National Health and Nutrition Examination Survey men, 2013-2014
Open Access
Author:
Ramsey, Pam Kelly
Graduate Program:
Public Health Sciences
Degree:
Master of Science
Document Type:
Master Thesis
Date of Defense:
November 02, 2018
Committee Members:
Alicia McDonald, Thesis Advisor/Co-Advisor Ping Du, Committee Member Duanping Liao, Committee Member
Keywords:
Human Papillomavirus Vitamin D
Abstract:
Human papillomavirus (HPV) is one of the most common sexually transmitted infections worldwide. Vitamin D has been showed to initiate an immune response against virus infections when activated. HPV prevalence has been shown to be associated with less-than-optimal levels of serum vitamin D in women, but has not been studied in men.
In the present study, our study population included 1689 males who participated in the National Health and Nutrition Examination Survey who had self-collected penile swabs with adequate HPV DNA laboratory data and 25-hydroxyvitamin D laboratory data between the years of 2013 and 2014. 25-hydroxyvitamin D was used as a vitamin D biomarker.
Logistic regression analysis was completed to analyze an association between serum 25-hydroxyvitamin D levels and overall HPV and high-risk HPV infection. After adjusting for race, age, marital status, number of female sexual partners, HIV status, men who have sex with men, and smoking status, we found no association between serum 25-hydroxyvitamin D levels and overall HPV (OR: 1.004; 95% CI: 0.991, 1.017) and HR-HPV infection (OR: 1.006; 95% CI: 0.987, 1.025). In conclusion, no association was found between 25-hydroxyvitamin D and HPV and HR-HPV infections among men.
