Electronic Circuit for Ultrasound Modulation

Open Access
Author:
Zhang, Enhao
Graduate Program:
Electrical Engineering
Degree:
Master of Science
Document Type:
Master Thesis
Date of Defense:
March 27, 2018
Committee Members:
  • Mehdi Kiani, Thesis Advisor
  • Weihua Guan, Committee Member
  • Sumeet Gupta, Committee Member
Keywords:
  • Pulsed ultrasound
  • Brain stimulation
  • Headstage
  • Commercial chip
  • PCB
  • Modulation
Abstract:
Recently, lots of experiments of Non-invasive brain stimulation has been carried out in small animals. Based on the previous research pulsed ultrasound under certain frequency and intensity has shown an effective control of animal reactions like moving tails and legs. The goal of this research is to build a headstage for mice that can generate ultrasound with accurate frequency and modulate the output ultrasound with different Pulse Repetition Frequency (PRF) as well as Sonication Duration (SD). The haeadstage will be applied in biological experiments and monitor the reactions from mice (moustache movement) under different ultrasound characteristics. The work of this research includes building block diagram for the whole circuit, selecting suitable commercial chips online and integrating them on a Printed Circuits Board (PCB). Plenty of testing is done to make sure that the circuit achieve the correct function and find the suitable values for components that achieve highest efficiency and output power. The testing results show that the circuits is able to generate ideal sine wave with 500kHz and 1MHz frequency. The class E power amplifier is able to deliver 10W power to the transducer with 60% efficiency. The modulation of ultrasound can be achieved by programming the micro-controller .