Gene Expression of Growth Plate Formation in Mouse Metatarsals
Open Access
Author:
Roberts, Catherine Elizabeth
Graduate Program:
Anthropology
Degree:
Master of Arts
Document Type:
Master Thesis
Date of Defense:
April 02, 2018
Committee Members:
Philip Reno, Thesis Advisor/Co-Advisor Timothy Michael Ryan, Committee Member
Keywords:
metatarsals growth plate bone development vertebrate evolution anthropology biology gene expression RNA-seq
Abstract:
Growth plates are structures which allow a bone to grow in length. The morphological evolution of the mammalian skeleton is characterized by changes in bone development, such as the loss or gain of growth plate formation in a particular bone. Differences in developmental processes are driven by differential gene expression both during organismal development and throughout their lifetime. This project uses mouse models to observe the genetic factors correlated with the presence or absence of growth plate formation in the metatarsal. The aim is to create a working list of genetic factors related to growth plate development.
