Electronic Theses and Dissertations for Graduate School
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Reagents for Improved Sensitivity in Point-of-Need Diagnostic Assays
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Brooks, Adam Dustin
Doctor of Philosophy
Date of Defense:
June 02, 2017
Scott T Phillips, Dissertation Advisor
Scott T Phillips, Committee Chair
Ken S Feldman, Committee Member
Benjamin James Lear, Committee Member
Michael Anthony Hickner, Outside Member
Point-of-need diagnostic assays are needed for providing sensitive and rapid measurements in environments where clean water, electricity, refrigeration, instrumentation, and technicians are not available. Assays meeting these requirements could also be of use in less limited environments, such as at home or in emergency rooms. At present, few assays meet these criteria, in part because of limitations in assay reagents. This thesis describes the design of several new reagents for use in point-of-need assays, with a focus on signal amplification and ease of readout.
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