1. Copper (II) Interactions with Phosphatidylserine in Membranes: Biophysical Insights, Binding Mechanisms, and Physiological Consequences Restricted (Penn State Only) Author: Reynolds, Christopher Title: Copper (II) Interactions with Phosphatidylserine in Membranes: Biophysical Insights, Binding Mechanisms, and Physiological Consequences Graduate Program: Chemistry Keywords: biophysical chemistrytransition metal ionsmembranescopper (II)oxidative damagesupported lipid bilayermicrofluidic systemsbindingphosphatidylserinelipidsstepwiseconstantsstoichiometrydensitiesconcentrationsGouy-Chapman theoryionic strengthsurface charge densitychelationcomplexesbuffer moleculesphysiological implicationsHeLa cellsplasma membranenecrotic cell deathhydrogen peroxideharmful effectsmechanistic explanationfuture experiments.hrmful effectsPhospholipid membranesoxidationcoppermembrane oxidationmembrane binding modelbivalent bindingDebye-Hukel TheoryElectrostatic screeningelectric double layerNecrotic cell deathcopper induced cell deathAlzheimer's diseaseNeurodegenerationmicrofluidic deviceshigh-throughput microfluidics File: Login to Download Committee Members: Paul Cremer, Chair & Dissertation AdvisorWilliam Hancock, Outside Unit & Field MemberAlexey Silakov, Major Field MemberLauren Zarzar, Major Field MemberPhilip Bevilacqua, Program Head/Chair
