1. Understanding the Role of Multiple Pathways in Enzyme Catalysis with a Hierarchical Markov State Model Open Access Author: Persichetti, Joseph Title: Understanding the Role of Multiple Pathways in Enzyme Catalysis with a Hierarchical Markov State Model Graduate Program: Chemistry Keywords: molecular dynamicsmarkov state modelQM/MMenzyme kineticsalanine dipeptidedihydrofolate reductasecomputationalfree-energy simulationsfinite-temperature string method File: Download Joseph_Persichetti_PhD_Thesis_FinalSubmission.pdf Committee Members: Lasse Jensen, Major Field MemberHoward Salis, Outside Unit & Field MemberEdward O'Brien, Chair & Dissertation AdvisorSquire Booker, Major Field MemberPhilip Bevilacqua, Program Head/Chair
