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Author:

Hayes, Daniel James

Title:

Micrototal Analysis System For Enzymatic Drug Metabolism and Analysis

Graduate Program:

Engineering Science and Mechanics

Keywords:

Cell Based Biosensor
Microfluidics
metabolism
drug discovery
mass spectrometry

File:

Download Dan__s_Thesis.pdf

Committee Members:

Sabih I Hayek, Committee Member
Osama O Awadelkarim, Committee Member
Gregory S Mc Carty, Committee Member
Seong H Kim, Committee Member
Stephen Joseph Fonash, Committee Chair/Co-Chair

Author:

Titchenell, Paul Michael

Title:

Targeting Atypical Protein Kinase C Isoforms for the Prevention of Blood-Retinal Barrier Dysfunction in Ophthalmic Disease

Graduate Program:

Physiology

Keywords:

vegf
drug discovery
PKC
blood-retinal barrier
vascular permeability
macular edema
phosphoproteomics
kinase inhibitor
TNF

File:

Download Titchenell_PM_Thesis_v2.pdf

Committee Members:

Charles H Lang, Dissertation Advisor/Co-Advisor
Charles H Lang, Committee Chair/Co-Chair
Thomas E Spratt, Committee Member
David Antonetti, Special Member
Yuguang Shi, Committee Member
Christopher Martin Yengo, Committee Member

Author:

Frieben, Emily

Title:

Dopamine D1-like receptors: Structure, function, and role in cancer therapeutics

Graduate Program:

Biomedical Sciences (PHD)

Keywords:

dopamine receptors
dopamine
GPCRs
neuropharmacology
functional selectivity
biased agonism
Parkinson's disease
cancer
chemotherapy
drug discovery

File:

Download Frieben_Dissertation_Final.pdf

Committee Members:

Richard Mailman, Co-Chair & Dissertation Advisor
Elizabeth Proctor, Outside Unit Member
Kent Vrana, Major Field Member
Daniel Morgan, Special Member
Nikolay Dokholyan, Co-Chair & Dissertation Advisor
Victor Ruiz-Velasco, Outside Field Member
Ralph Keil, Program Head/Chair