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Author:

Reynolds, Christopher

Title:

Copper (II) Interactions with Phosphatidylserine in Membranes: Biophysical Insights, Binding Mechanisms, and Physiological Consequences

Graduate Program:

Chemistry (PHD)

Keywords:

biophysical chemistry
transition metal ions
membranes
copper (II)
oxidative damage
supported lipid bilayer
microfluidic systems
binding
phosphatidylserine
lipids
stepwise
constants
stoichiometry
densities
concentrations
Gouy-Chapman theory
ionic strength
surface charge density
chelation
complexes
buffer molecules
physiological implications
HeLa cells
plasma membrane
necrotic cell death
hydrogen peroxide
harmful effects
mechanistic explanation
future experiments.
hrmful effects
Phospholipid membranes
oxidation
copper
membrane oxidation
membrane binding model
bivalent binding
Debye-Hukel Theory
Electrostatic screening
electric double layer
Necrotic cell death
copper induced cell death
Alzheimer's disease
Neurodegeneration
microfluidic devices
high-throughput microfluidics

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Committee Members:

Paul Cremer, Chair & Dissertation Advisor
William Hancock, Outside Unit & Field Member
Alexey Silakov, Major Field Member
Lauren Zarzar, Major Field Member
Philip Bevilacqua, Program Head/Chair