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1. Does the H67D HFE genotype impact macrophage phenotype and disease process?

open_access
Open Access
Author:
Nixon, Anne Marie
Title:
Does the H67D HFE genotype impact macrophage phenotype and disease process?
Graduate Program:
Anatomy
Keywords:
Iron
HFE
Macrophages
Parkinson's Disease
Paraquat
Neurodegeneration
File:
Download Nixon_AM_Dissertation.pdf
Committee Members:
James R. Connor, Dissertation Advisor/Co-Advisor
James R. Connor, Committee Chair/Co-Chair
Gregory M. Holmes, Committee Member
Patricia J. McLaughlin, Committee Member
Robert F. Paulson, Outside Member

2. NOVEL MODEL FOR LOADING BRAIN IRON IN MICE: IMPLICATIONS FOR STUDYING AGING AND AMYLOID PATHOLOGY

open_access
Open Access
Author:
Peters, Douglas Gordon
Title:
NOVEL MODEL FOR LOADING BRAIN IRON IN MICE: IMPLICATIONS FOR STUDYING AGING AND AMYLOID PATHOLOGY
Graduate Program:
Neuroscience
Keywords:
Alzheimer's disease
Iron
Aging
MRI
Histology
Neurodegeneration
File:
Download Peters_Thesis_FINAL.pdf
Committee Members:
Mark David Meadowcroft, Dissertation Advisor/Co-Advisor
James Robert Connor, Committee Chair/Co-Chair
Qing X Yang, Committee Member
Paul Eslinger, Committee Member
Ralph Lauren Keil, Outside Member

3. Ucp2-Dependent Changes in Mitochondrial Dynamics Protect the Retina from Glaucoma

open_access
Open Access
Author:
Hass, Daniel
Title:
Ucp2-Dependent Changes in Mitochondrial Dynamics Protect the Retina from Glaucoma
Graduate Program:
Neuroscience
Keywords:
Ucp2
Glaucoma
Mitochondria
Oxidative Stress
Uncoupling
Eye
Retina
Neurodegeneration
File:
Download DTH-Thesis-Final-3.pdf
Committee Members:
Colin James Barnstable, Dissertation Advisor/Co-Advisor
Colin James Barnstable, Committee Chair/Co-Chair
Ian Alexander Simpson, Committee Member
Alistair J Barber, Committee Member
Gregory Steven Yochum, Outside Member
Daniel James Morgan, Committee Member

4. H63D HFE as a genetic modifier of Parkinson's disease: clinical impacts and molecular mechanisms

open_access
Open Access
Author:
Kim, Yunsung
Title:
H63D HFE as a genetic modifier of Parkinson's disease: clinical impacts and molecular mechanisms
Graduate Program:
Biomedical Sciences
Keywords:
Parkinson's disease
Neurodegeneration
Iron
HFE
Autophagy
Alpha-synuclein
File:
Download YK_Dissertation_Final.pdf
Committee Members:
James Robert Connor, Dissertation Advisor/Co-Advisor
James Robert Connor, Committee Chair/Co-Chair
Salvatore Lucia Stella, Jr., Committee Member
Xuemei Huang, Committee Member
Robert G Levenson, Outside Member
Mark C. Stahl, Special Member
Ralph Lauren Keil, Program Head/Chair

5. Copper (II) Interactions with Phosphatidylserine in Membranes: Biophysical Insights, Binding Mechanisms, and Physiological Consequences

restricted_to_institution
Restricted (Penn State Only)
Author:
Reynolds, Christopher
Title:
Copper (II) Interactions with Phosphatidylserine in Membranes: Biophysical Insights, Binding Mechanisms, and Physiological Consequences
Graduate Program:
Chemistry (PHD)
Keywords:
biophysical chemistry
transition metal ions
membranes
copper (II)
oxidative damage
supported lipid bilayer
microfluidic systems
binding
phosphatidylserine
lipids
stepwise
constants
stoichiometry
densities
concentrations
Gouy-Chapman theory
ionic strength
surface charge density
chelation
complexes
buffer molecules
physiological implications
HeLa cells
plasma membrane
necrotic cell death
hydrogen peroxide
harmful effects
mechanistic explanation
future experiments.
hrmful effects
Phospholipid membranes
oxidation
copper
membrane oxidation
membrane binding model
bivalent binding
Debye-Hukel Theory
Electrostatic screening
electric double layer
Necrotic cell death
copper induced cell death
Alzheimer's disease
Neurodegeneration
microfluidic devices
high-throughput microfluidics
File:
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Committee Members:
Paul Cremer, Chair & Dissertation Advisor
William Hancock, Outside Unit & Field Member
Alexey Silakov, Major Field Member
Lauren Zarzar, Major Field Member
Philip Bevilacqua, Program Head/Chair