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Author:

Han, Feng

Title:

INVESTIGATE THE ROLE OF GLOBAL BRAIN ACTIVITY IN NEURODEGENERATION AND AGING

Graduate Program:

Bioengineering

Keywords:

Resting-state functional magnetic resonance imaging
global brain activity
global signal
glymphatic system
amyloid-β
cross-hierarchy difference
Alzheimer's disease
cerebrospinal fluid
Parkinson’s disease
healthy aging
the coupling between the global brain and the cerebrospinal fluid fMRI signals

File:

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Committee Members:

Xiao Liu, Chair & Dissertation Advisor
Nanyin Zhang, Major Field Member
Michele Diaz, Major Field Member
Daniel Hayes, Program Head/Chair
Xuemei Huang, Outside Unit & Field Member
Xiang Zhang, Outside Field Member

Author:

Reynolds, Christopher

Title:

Copper (II) Interactions with Phosphatidylserine in Membranes: Biophysical Insights, Binding Mechanisms, and Physiological Consequences

Graduate Program:

Chemistry

Keywords:

biophysical chemistry
transition metal ions
membranes
copper (II)
oxidative damage
supported lipid bilayer
microfluidic systems
binding
phosphatidylserine
lipids
stepwise
constants
stoichiometry
densities
concentrations
Gouy-Chapman theory
ionic strength
surface charge density
chelation
complexes
buffer molecules
physiological implications
HeLa cells
plasma membrane
necrotic cell death
hydrogen peroxide
harmful effects
mechanistic explanation
future experiments.
hrmful effects
Phospholipid membranes
oxidation
copper
membrane oxidation
membrane binding model
bivalent binding
Debye-Hukel Theory
Electrostatic screening
electric double layer
Necrotic cell death
copper induced cell death
Alzheimer's disease
Neurodegeneration
microfluidic devices
high-throughput microfluidics

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Committee Members:

Paul Cremer, Chair & Dissertation Advisor
William Hancock, Outside Unit & Field Member
Alexey Silakov, Major Field Member
Lauren Zarzar, Major Field Member
Philip Bevilacqua, Program Head/Chair

Author:

Chan, Dennis

Title:

Elucidating the Relationship between Neuroinflammation and Functional Connectivity over the Progression of Alzheimer’s Disease

Graduate Program:

Bioengineering

Keywords:

Alzheimer's disease
Neuroimaging
Neuroscience
Neuroinflammation
Network Analysis

File:

Download Thesis_Dennis_Chan.pdf

Committee Members:

Elizabeth Proctor, Co-Chair & Dissertation Advisor
Xiao Liu, Major Field Member
Justin Pritchard, Major Field Member
Nanyin Zhang, Co-Chair & Dissertation Advisor
Daniel Hayes, Program Head/Chair
Patrick Drew, Outside Unit & Field Member

Author:

Wang, Yue

Title:

MECHANISTIC STUDY OF ALZHEIMER’S DISEASE AND NEUROD1-MEDIATED IN VIVO CELL CONVERSION

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Alzheimer's disease
NeuroD1
Cell conversion
Beneficial effect
GAD67
Haploinsufficiency
Small molecule cocktail
Therapy
In vivo

File:

Download 2018_Spring_PhD_thesis-Yue_Wang.pdf

Committee Members:

Gong Chen, Dissertation Advisor/Co-Advisor
Douglas Cavener, Committee Chair/Co-Chair
Bernhard Luscher, Committee Member
Kevin Douglas Alloway, Committee Member
Yingwei Mao, Outside Member