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Start Over Graduate Program Molecular, Cellular and Integrative Biosciences Committee Member Zhi-Chun Lai

1. THE REGULATION OF ER CHAPERONES AND PROINSULIN PROTEOSTASIS BY PERK EIF2ALPHA KINASE

open_access
Open Access
Author:
Lewis, Carrie Rebekah
Title:
THE REGULATION OF ER CHAPERONES AND PROINSULIN PROTEOSTASIS BY PERK EIF2ALPHA KINASE
Graduate Program:
Molecular, Cellular and Integrative Biosciences
Keywords:
proinsulin
ER chaperones
PERK
EIF2AK3
File:
Download CL_Thesis_Dissertation_FINAL_edited_with_corrections_7-14-16.pdf
Committee Members:
Douglas Cavener, Dissertation Advisor/Co-Advisor
Melissa Rolls, Committee Chair/Co-Chair
Zhi-Chun Lai, Committee Member
Douglas Cavener, Committee Member
Yanming Wang, Outside Member

2. A NOVEL SMALL MOLECULE DNA INTERCALATOR PZ1225 IN CANCER CELL APOPTOSIS AND A HISTONE MODIFIER PAD4 IN MACROPHAGE EXTRACELLULAR TRAP FORMATION

open_access
Open Access
Author:
sun, jinquan
Title:
A NOVEL SMALL MOLECULE DNA INTERCALATOR PZ1225 IN CANCER CELL APOPTOSIS AND A HISTONE MODIFIER PAD4 IN MACROPHAGE EXTRACELLULAR TRAP FORMATION
Graduate Program:
Molecular, Cellular and Integrative Biosciences
Keywords:
DNA damage
DNA intercalator
small molecule
MAPK
mTOR
apoptosis
macrophage
extracellular traps
PAD4
citrullination
stroke
File:
Download Graduation_Thesis-Jinquan-20161201.pdf
Committee Members:
Yanming Wang, Dissertation Advisor/Co-Advisor
Zhi-Chun Lai, Committee Chair/Co-Chair
Douglas Cavener, Committee Member
Lu Bai, Committee Member
Robert Paulson, Outside Member

3. PHENOTYPIC AND GENETIC CHARACTERIZATION OF NON-SMALL CELL LUNG CANCER CIRCULATING TUMOR CELLS

open_access
Open Access
Author:
Nisic, Merisa
Title:
PHENOTYPIC AND GENETIC CHARACTERIZATION OF NON-SMALL CELL LUNG CANCER CIRCULATING TUMOR CELLS
Graduate Program:
Molecular, Cellular and Integrative Biosciences
Keywords:
Circulating Tumor Cell
Enrichment
Microfiltration
Lung Cancer
File:
Download Merisa_Nisic_Dissertation_FINAL.pdf
Committee Members:
Siyang Zheng, Dissertation Advisor/Co-Advisor
Siyang Zheng, Committee Chair/Co-Chair
Jian Yang, Committee Member
Zhi-Chun Lai, Committee Member
Andrea Marie Mastro, Outside Member

4. THE FUNCTION AND REGULATION OF A TRANSCRIPTIONAL CO-ACTIVATOR YAP IN GROWTH CONTROL AND TISSUE HOMEOSTASIS

open_access
Open Access
Author:
Matsui, Yurika
Title:
THE FUNCTION AND REGULATION OF A TRANSCRIPTIONAL CO-ACTIVATOR YAP IN GROWTH CONTROL AND TISSUE HOMEOSTASIS
Graduate Program:
Molecular, Cellular and Integrative Biosciences
Keywords:
Hippo pathway
Yes-associated protein (YAP)
cell proliferation
apoptosis
isoform
pancreatic beta-cell
large tumor suppressor kinase 1 (LATS1)
File:
Download PhDdissertation_YurikaMatsui.pdf
Committee Members:
Zhi-Chun Lai, Dissertation Advisor/Co-Advisor
Douglas Cavener, Committee Chair/Co-Chair
Melissa Rolls, Committee Member
Michael Axtell, Committee Member
Lorraine C Santy, Outside Member

5. Regulation of stress erythropoiesis via splenic erythroid microenvironment development and metabolic programming

open_access
Open Access
Author:
Hao, Siyang
Title:
Regulation of stress erythropoiesis via splenic erythroid microenvironment development and metabolic programming
Graduate Program:
Molecular, Cellular and Integrative Biosciences
Keywords:
stress erythropoiesis
splenic erythroid niche
cellular metabolism
growth-differentiation factor 15
glucocorticoids
Yes-associated protein
File:
Download Siyang_Hao_dissertation_.pdf
Committee Members:
Robert F. Paulson, Dissertation Advisor/Co-Advisor
Zhi-Chun Lai, Committee Chair/Co-Chair
K. Sandeep Prabhu, Committee Member
Andrew D. Patterson, Committee Member
Xiaojun (Lance) Lian, Outside Member

7. NOVEL SIGNALS IN STRESS ERYTHROPOIESIS: COORDINATED CONTROL OF WNT, PGE2 AND PERK SIGNALING PATHWAYS REGULATES EXPANSION AND DIFFERENTIATION OF STRESS ERYTHROID PROGENITORS

open_access
Open Access
Author:
Chen, Yuanting
Title:
NOVEL SIGNALS IN STRESS ERYTHROPOIESIS: COORDINATED CONTROL OF WNT, PGE2 AND PERK SIGNALING PATHWAYS REGULATES EXPANSION AND DIFFERENTIATION OF STRESS ERYTHROID PROGENITORS
Graduate Program:
Molecular, Cellular and Integrative Biosciences
Keywords:
Stress erythropoiesis
Wnt
PGE2
PERK
mTORC1
File:
Download Thesis_2nd_Yuanting_Chen.pdf
Committee Members:
Robert Paulson, Dissertation Advisor/Co-Advisor
Robert Paulson, Committee Chair/Co-Chair
Kumble Sandeep Prabhu, Committee Member
Zhi-Chun Lai, Committee Member
Xiaojun Lance Lian, Outside Member
Wendy Hanna-Rose, Committee Member
Melissa Rolls, Program Head/Chair

8. Co-opting regulation bypass repair (CRBR) as gene editing strategy in mouse and human pancreatic beta cells

open_access
Open Access
Author:
Hu, Jingjie
Title:
Co-opting regulation bypass repair (CRBR) as gene editing strategy in mouse and human pancreatic beta cells
Graduate Program:
Molecular, Cellular and Integrative Biosciences
Keywords:
CRISPR/Cas9
gene editing
CRBR
monogenic disease
rare disease
Wolcott-Rallison syndrome
PERK(EIF2AK3)
Insulin
diabetes
File:
Download J_Hu_Dissertation_Final_3-24-2021.pdf
Committee Members:
Douglas Cavener, Dissertation Advisor/Co-Advisor
Douglas Cavener, Committee Chair/Co-Chair
Zhi-Chun Lai, Committee Member
Yingwei Mao, Committee Member
Melissa Rolls, Outside Member
Timothy J Jegla, Committee Member
Melissa Rolls, Program Head/Chair