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Author:

Byrska-bishop, Marta Barbara

Title:

Unraveling the mechanism of GATA1s-mediated blood disorders using functional genomics in pluripotent stem cells

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

blood disorders
hematopoiesis
GATA1 transcription factor
transcriptome analysis
induced pluripotent stem cells

File:

Download ByrskaBishop_Dissertation_060215.pdf

Committee Members:

Ross Cameron Hardison, Dissertation Advisor/Co-Advisor
Ross Cameron Hardison, Committee Chair/Co-Chair
Santhosh Girirajan, Committee Member
Qunhua Li, Committee Member
Marylyn Deriggi Ritchie, Committee Member
Melissa Rolls, Committee Member

Author:

Wang, Qingyu

Title:

Evaluation of whole exome sequencing technology in cohort dataset and quantification of phenotypic alterations in a model organism

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Whole Exome Sequencing
low coverage
unevenness
Drosophila melanogaster
eye phenotype
image processing
quantitative assessment

File:

Download QWFinal_dissertation.pdf

Committee Members:

Naomi S Altman, Dissertation Advisor/Co-Advisor
Santhosh Girirajan, Dissertation Advisor/Co-Advisor
Ross Cameron Hardison, Committee Member
Shaun A Mahony, Committee Member
Cooduvalli S Shashikant, Committee Member

Author:

Hu, Kai

Title:

Bioinformatics discovery of chemical diversity in enzyme superfamilies

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Ribonucleotide Reductase (RNR)
Bioinformatics
Radical chemistry
Class Ie RNR
Deep Mutational Scanning (DMS) strategy

File:

Download Kai_Hu_dissertation_for_submission.pdf

Committee Members:

Benjamin D Allen, Dissertation Advisor/Co-Advisor
Joseph M Bollinger, Jr., Committee Chair/Co-Chair
Amie Kathleen Boal, Outside Member
Ross Cameron Hardison, Committee Member
Melissa Rolls, Program Head/Chair

Author:

Jiang, Haoyang

Title:

CHARACTERIZATION OF THE FUNCTIONS OF THE CCR4-NOT COMPLEX IN DNA DAMAGE RESPONSE

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Ccr4-Not complex
RNAPII ubiquitination
Transcription and DNA damage repair

File:

Download Haoyang_Jiang_Thesis-V12.pdf

Committee Members:

Joseph C. Reese, Dissertation Advisor/Co-Advisor
Joseph C. Reese, Committee Chair/Co-Chair
David Scott Gilmour, Committee Member
Ross Cameron Hardison, Committee Member
Tae-Hee Lee, Outside Member
Melissa Rolls, Program Head/Chair