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Author:

Dang Do, An Ngoc

Title:

The eIF2 alpha Kinases GCN2 and PERK Regulate Phosphorylation of TOR Target Proteins and Differential Translation of mRNAs

Graduate Program:

Integrative Biosciences

Keywords:

2
cycloheximide
4-di-tert-butylhydroquinone
translation initiation
translation elongation
eIF2
eIF2B
4E-BP1
GCN2
p70S6K1
PERK
TOR
methionine deprivation
leucine deprivation
polysome
microarray
QRT-PCR
histidinol
leucinol
sucrose gradient
atf4
atf5
slc3a2
slc3a3
trfr
ldlr
stch
hspa5
igfbp-2

File:

Download An_Do_thesis_2008.pdf

Committee Members:

Leonard Shelton Jefferson Jr., Committee Chair/Co-Chair
Scot R Kimball, Committee Member
Ralph Lauren Keil, Committee Member
Douglas Cavener, Committee Member
Robert A Gabbay, Committee Member

Author:

Zou, Beiyan

Title:

A ROLE FOR MAP1 IN SYNAPTIC FUNCTION REVEALED THROUGH INTERACTIONS WITH PRESYNAPTIC CALCIUM CHANNELS IN DROSOPHILA

Graduate Program:

Genetics

Keywords:

synaptic transmission
MAP1
presynaptic calcium channel
cacophony
futsch
Drosophila

File:

Download Ph.D_dissertation_from_Beiyan_Zou.pdf

Committee Members:

Douglas Cavener, Committee Chair/Co-Chair
Gong Chen, Committee Member
Kyung An Han, Committee Member
Zhi Chun Lai, Committee Member
Richard W Ordway, Committee Member

Author:

Fang, Cheng

Title:

Structural and Functional Modulation of Inhibitory Synapses by GODZ-mediated Palmitoylation of GABAA Receptors

Graduate Program:

Biology

Keywords:

trafficking
synaptogenesis
inhibitory synapses
palmitoylation
GABAA receptors
DHHC-CRD proteins

File:

Download Cheng_Thesis_April17.pdf

Committee Members:

Bernhard Luscher, Committee Chair/Co-Chair
Douglas Cavener, Committee Member
Gong Chen, Committee Member
Erin Elizabeth Sheets, Committee Member
Wendy Hanna Rose, Committee Member

Author:

Hsu, Chia-Ling

Title:

The role of the Kar2p/BiP chaperone in ER quality control

Graduate Program:

Biochemistry, Microbiology, and Molecular Biology

Keywords:

ER sress tolerance
unfolded protein response
ER quality control
Kar2p/BiP

File:

Download Microsoft_Word_-_Chapter1-another_copy_for_graduate_school.pdf

Committee Members:

Wesley Tsoekjen Ng, Committee Chair/Co-Chair
Sarah Ellen Ades, Committee Member
David Scott Gilmour, Committee Member
Douglas Cavener, Committee Member

Author:

Chalkia, Dimitra

Title:

ORIGINS AND EVOLUTION OF THREE MULTIDOMAIN GENE FAMILIES CONCERNED WITH BASIC CELLULAR AND DEVELOPMENTAL PROCESSES IN EUKARYOTES

Graduate Program:

Biology

Keywords:

evolution
protein domain
functional divergence
formin

File:

Download Dimitra_Chalkia_PhD_Thesis.pdf

Committee Members:

Douglas Cavener, Committee Chair/Co-Chair
Masatoshi Nei, Committee Member
Jan Klein, Committee Member
Bernhard Luscher, Committee Member
Ross Cameron Hardison, Committee Member

Author:

Wu, Dai-Chen

Title:

FROM EXPLORING ROLES OF SIGNALS IN STRESS ERYTHROPOIESIS TO IN VITRO EXPANDING STRESS ERYTHROID PROGENITORS THAT ALLEVIATE ANEMIA

Graduate Program:

Biochemistry, Microbiology, and Molecular Biology

Keywords:

Hedgehog
BMP4
hypoxia
hematopoiesis
erythropoiesis
GDF15
anemia
stem cell

File:

Download DC_Wu_Dissertation_Final_renumbered.pdf

Committee Members:

Robert Paulson, Dissertation Advisor/Co-Advisor
Robert Paulson, Committee Member
Douglas Cavener, Committee Member
David Scott Gilmour, Committee Member
Pamela Hankey Giblin, Committee Member
Ross Cameron Hardison, Committee Member

Author:

Preston, Holly

Title:

EFFECTS OF EXERCISE AND GENETIC STRAIN ON BONE STRENGTH, MUSCULOSKELETAL GENE EXPRESSION AND ACTIVITY LEVELS IN C57BL/6J AND DBA/2J ADULT FEMALE MICE

Graduate Program:

Kinesiology

Keywords:

exercise
bone
muscle
inbred mice
genetics
biomechanics

File:

Download HOLLY_PRESTON_DISSERTATION.pdf

Committee Members:

Neil Sharkey, Dissertation Advisor/Co-Advisor
Teresa Caroldean Lang, Committee Chair/Co-Chair
Neil Sharkey, Committee Chair/Co-Chair
Robert Barry Eckhardt, Committee Member
Douglas Cavener, Committee Member

Author:

Wei, Jianwen

Title:

PERK IS ESSENTIAL FOR NEONATAL SKELETAL DEVELOPMENT TO REGULATE OSTEOBLAST BIOLOGY

Graduate Program:

Genetics

Keywords:

PERK
osteoblast
Runx2
procollagen
proliferation
endoplasmic reticulum

File:

Download Jianwen_Thesis.pdf

Committee Members:

Zhi Chun Lai, Committee Chair/Co-Chair
Douglas Cavener, Committee Member
Richard W Ordway, Committee Member
Carol V Gay, Committee Member
Pamela J Mitchell, Committee Member

Author:

Estes, Kathleen Anne

Title:

ANALYSIS OF C. ELEGANS VULVAL MORPHOGENESIS REVEALS NOVEL MECHANISMS FOR INITIATION AND MAINTENANCE OF BIOLOGICAL TUBES

Graduate Program:

Biochemistry, Microbiology, and Molecular Biology

Keywords:

tubulogenesis
lumen
anchor cell
c. elegans
development
vulva
egl-26
NlpC/p60

File:

Download ThesisMaster_FINAL.pdf

Committee Members:

Wendy Hanna Rose, Dissertation Advisor/Co-Advisor
Wendy Hanna Rose, Committee Chair/Co-Chair
Melissa Rolls, Committee Member
Lorraine C Santy, Committee Member
Douglas Cavener, Committee Member
Zhi Chun Lai, Committee Member

Author:

Iida, Kaori

Title:

Functions of PERK eIF2 Alpha Kinase in the Mouse Exocrine Pancreas

Graduate Program:

Genetics

Keywords:

acinar cells
oncosis
pancreatitis
PERK
ER stress

File:

Download eTD.pdf

Committee Members:

Douglas Cavener, Committee Member
Diana Lynn Cox Foster, Committee Chair/Co-Chair
Richard W Ordway, Committee Member
Ross Cameron Hardison, Committee Member
Pamela J Mitchell, Committee Member

Author:

Ho, Li-Lun

Title:

MOB as Tumor Suppressor is Activated at the Plasma Membrane to Control Tissue Growth and Organ size in Drosophila

Graduate Program:

Integrative Biosciences

Keywords:

Mats
tumor suppressor
Hippo signaling
organ size control

File:

Download Thesis__Li-Lun_Ho.pdf

Committee Members:

Zhi Chun Lai, Dissertation Advisor/Co-Advisor
Zhi Chun Lai, Committee Chair/Co-Chair
Avery August, Committee Member
Douglas Cavener, Committee Member
Richard John Frisque, Committee Member
Aimin Liu, Committee Member
Robert Paulson, Committee Member
Peter John Hudson, Committee Member

Author:

Cheng, Lin

Title:

Role of the tmRNA pathway in bacterial physiology and its use in antibiotic development

Graduate Program:

Genetics

Keywords:

antibacterial cyclic peptide
DnaA
ClpXP
DNA replication
tmRNA
cell cycle regulation

File:

Download Lin_Cheng_dissertation.pdf

Committee Members:

Paul Lee Babitzke, Committee Chair/Co-Chair
Kenneth Charles Keiler, Committee Member
Stephen James Benkovic, Committee Member
Douglas Cavener, Committee Member
Eric Thomas Harvill, Committee Member

Author:

Darlington, Mark Burton

Title:

SEXUAL SELECTION IN THE SPOTTED CUCUMBER BEETLE, DIABROTICA UNDECIMPUNCTATA HOWARDI (COLEOPTERA: CHRYSOMELIDAE): MALE TRAITS FAVORED BY CRYPTIC FEMALE CHOICE.

Graduate Program:

Biology

Keywords:

sexual selection
cryptic female choice
mating display rate

File:

Download Darlington_thesis.pdf

Committee Members:

James Harold Marden, Committee Chair/Co-Chair
Andrew George Stephenson, Committee Member
Shelby Jay Fleischer, Committee Member
Mark C Mescher, Committee Member
Douglas Cavener, Committee Member

Author:

Alldred, Melissa J

Title:

AN INVESTIGATION OF THE DOMAINS OF THE GAMMA TWO SUBUNIT OF GABAA RECEPTORS, GEPHYRIN AND COLLYBISTIN REQUIRED FOR SYNAPTIC LOCALIZATION

Graduate Program:

Biochemistry, Microbiology, and Molecular Biology

Keywords:

GABA-A receptors
gephyrin
collybistin
synaptic localization

File:

Download Mel_PHD_thesis1.pdf

Committee Members:

Bernhard Luscher, Committee Chair/Co-Chair
Graham Hugh Thomas, Committee Member
Douglas Cavener, Committee Member
Randen Patterson, Committee Member
Benjamin Franklin Pugh, Committee Member

Author:

Porayette, Prashanth

Title:

THE BMP4-SMAD5 SIGNALING PATHWAY IS REQUIRED FOR THE RAPID EXPANSION OF ERYTHROID PROGENITORS IN THE EMBRYO

Graduate Program:

Integrative Biosciences

Keywords:

fetal liver
BMP4
Smad5
erythropoiesis

File:

Download Porayette_Dissertation.pdf

Committee Members:

Robert Paulson, Committee Chair/Co-Chair
Avery August, Committee Member
Pamela Hankey, Committee Member
Douglas Cavener, Committee Member
Andrew Thomas Henderson, Committee Member
Peter John Hudson, Committee Member

Author:

Wang, Qian

Title:

REGULATION OF NEUROPEPTIDE Y EXPRESSION AND THE SYMPATHO-ADRENAL RESPONSE TO STRESS

Graduate Program:

Cell and Developmental Biology

Keywords:

neuropeptide Y
catecholamines
stress
adrenal medulla

File:

Download Qian_Wang_923512678_CDB_PhD_Dissertation_2011_Aug_Final_submission_.pdf

Committee Members:

Douglas Cavener, Dissertation Advisor/Co-Advisor
Douglas Cavener, Committee Chair/Co-Chair
Matthew Whim, Committee Chair/Co-Chair
Bernhard Luscher, Committee Member
Melissa Rolls, Committee Member
Byron C Jones, Committee Member

Author:

Shen, Qiuying

Title:

INVESTIGATION OF THE BRAIN SUBSTRATES OF ANXIOUS DEPRESSION

Graduate Program:

Biochemistry, Microbiology, and Molecular Biology

Keywords:

HPA axis
GABA
anxious depression
critical period

File:

Download Qiuying_thesis_0714.pdf

Committee Members:

Bernhard Luscher, Dissertation Advisor/Co-Advisor
Bernhard Luscher, Committee Chair/Co-Chair
Douglas Cavener, Committee Member
Wendy Hanna Rose, Committee Member
Debashis Ghosh, Committee Member
Jeffrey Maurice Peters, Committee Member
Robert Paulson, Committee Member

Author:

Riddle, Ryan Christopher

Title:

Biophysical Regulation of Human Mesenchymal Stem Cell Proliferation

Graduate Program:

Cell and Molecular Biology

Keywords:

Osteoporosis
Mesenchymal stem cell
Orthopaedics

File:

Download Thesis_Final_Draft_.pdf

Committee Members:

Henry Joseph Donahue, Committee Chair/Co-Chair
Sarah Bronson, Committee Member
Douglas Cavener, Committee Member
Christopher J Lynch, Committee Member
Timothy Ritty, Committee Member

Author:

Schilder, Rudolf

Title:

Mechanics, Metabolism & Menosporinae: An integrative analysis of dragonfly flight performance

Graduate Program:

Biology

Keywords:

mechanics
metabolism
muscle
insect flight muscle
infection
gregarine
parasite

File:

Download RJ_Schilder_Thesis.pdf

Committee Members:

James Harold Marden, Committee Chair/Co-Chair
Douglas Cavener, Committee Member
Richard W Ordway, Committee Member
Diana Lynn Cox Foster, Committee Member

Author:

Gupta, Sounak

Title:

PERK (EIF2AK3) REGULATES PROINSULIN TRAFFICKING AND QUALITY CONTROL IN THE SECRETORY PATHWAY

Graduate Program:

Molecular Medicine

Keywords:

DIABETES
TRAFFICKING
PERK
INSULINOMA
ENDOPLASMIC RETICULUM
PROINSULIN

File:

Download SounakGupta-Thesis-Aug2010.pdf

Committee Members:

Douglas Cavener, Dissertation Advisor/Co-Advisor
Douglas Cavener, Committee Member
Robert Paulson, Committee Chair/Co-Chair
Zhi Chun Lai, Committee Member
Wendy Hanna Rose, Committee Member
Kouacou Konan, Committee Member

Author:

Yu, Wenhua

Title:

IN VIVO FUNCTION AND INTERACTION OF SNARES, NSF AND SNAP DURING PRESYNAPTIC VESICLE TRAFFICKING IN DROSOPHILA

Graduate Program:

Genetics

Keywords:

synaptic function
NSF
SNAP
SNAREs
live imaging
FRET
Drosophila

File:

Download Wenhua_Yu_Dissertation.pdf

Committee Members:

Richard W Ordway, Dissertation Advisor/Co-Advisor
Zhi Chun Lai, Committee Chair/Co-Chair
Richard W Ordway, Committee Member
Wendy Hanna Rose, Committee Member
Aimin Liu, Committee Member
Douglas Cavener, Committee Member

Author:

Zhang, Wei

Title:

FUNCTIONS OF PERK eIF2-alpha KINASE IN THE MOUSE PANCREATIC Beta-CELLS

Graduate Program:

Genetics

Keywords:

ER stress
PERK
eIF2-alpha
Beta-cell
hypoplasia

File:

Download Ph.D._thesis_wei_2007_PSU.pdf

Committee Members:

Douglas Cavener, Committee Member
Richard W Ordway, Committee Chair/Co-Chair
Pamela Hankey Giblin, Committee Member
Gong Chen, Committee Member

Author:

Xu, Xu

Title:

The GCN2 eIF2alpha kinase regulates lipid and glucose homeostasis

Graduate Program:

Cell and Developmental Biology

Keywords:

GCN2
FSP27
Triglyceride Storage
Insig2a
C/EBPbeta
Gluconeogenesis

File:

Download 11282011_Xu_Xu_Ph.D_thesis_final_eTD.pdf

Committee Members:

Douglas Cavener, Dissertation Advisor/Co-Advisor
Gong Chen, Committee Chair/Co-Chair
Douglas Cavener, Committee Member
Zhi Chun Lai, Committee Member
Robert Paulson, Committee Member

Author:

Wei, Xiaomu

Title:

Control of Cell Proliferation and Apoptosis by Mob as Tumor Suppressor Protein

Graduate Program:

Genetics

Keywords:

hippo
growth inhibition and tumor suppression
Drosophila
mats
warts

File:

Download Xiaomu_Wei.pdf

Committee Members:

Richard W Ordway, Committee Chair/Co-Chair
Zhi Chun Lai, Committee Member
Douglas Cavener, Committee Member
Gong Chen, Committee Member
Wendy Hanna Rose, Committee Member

Author:

Yuan, Xu

Title:

STRUCTURAL AND FUNCTIONAL ANALYSES OF A NOVEL INTERACTION BETWEEN GABA-A RECEPTORS AND CAML

Graduate Program:

Genetics

Keywords:

calcium modulating cyclophilin ligand
trafficking
GABA-A receptor

File:

Download xu_yuan_thesis.PDF

Committee Members:

Richard W Ordway, Committee Chair/Co-Chair
Bernhard Luscher, Committee Member
Gong Chen, Committee Member
Douglas Cavener, Committee Member
Pamela Hankey Giblin, Committee Member

Author:

Zhang, Ying

Title:

Distinctive Genomic Features of Erythroid Cis-Regulatory Modules

Graduate Program:

Genetics

Keywords:

Cis-Regulatory Modules
GATA1
ESPERR
Word Enumeration
ChIP

File:

Download Thesis.pdf

Committee Members:

Ross Cameron Hardison, Dissertation Advisor/Co-Advisor
Robert Paulson, Committee Chair/Co-Chair
Ross Cameron Hardison, Committee Member
Douglas Cavener, Committee Member
Francesca Chiaromonte, Committee Member
Kateryna Dmytrivna Makova, Committee Member

Author:

LI, YULIN

Title:

The growth retardation and liver dysfunction of PERK knockout mice

Graduate Program:

Genetics

Keywords:

PERK
Liver dysfunction
Steatosis
Wolcott-Rallison syndrome
growth retardation
EIF2AK3

File:

Download Thesis-YULIN--format_review.pdf

Committee Members:

Douglas Cavener, Committee Member
Gong Chen, Committee Member
Bernhard Luscher, Committee Chair/Co-Chair
Richard W Ordway, Committee Member
Robert Paulson, Committee Member

Author:

Sun, Chicheng

Title:

The function of neuroligin-2 in neuronal development and neuropsychiatric disorders

Graduate Program:

Cell and Developmental Biology

Keywords:

Neuroligin
Synapse
GABA
Schizophrenia
KCC2

File:

Download Chicheng_Sun_Thesis.pdf

Committee Members:

Gong Chen, Dissertation Advisor/Co-Advisor
Douglas Cavener, Committee Chair/Co-Chair
Zhi Chun Lai, Committee Member
Richard W Ordway, Committee Member
Rick Owen Gilmore, Committee Member

Author:

Yu, Shan

Title:

Regulation of Macrophage Heterogeneity and Diet-induced Metabolic Diseases by the Receptor Tyrosine Kinase Ron

Graduate Program:

Physiology

Keywords:

Receptor tyrosine kinase
Ron
atherosclerosis
obesity
fatty liver disease
macrophage activation
inflammation

File:

Download 7-26-13_Shan_Yu_thesis.pdf

Committee Members:

Pamela Hankey Giblin, Dissertation Advisor/Co-Advisor
Donna Hope Korzick, Committee Chair/Co-Chair
Kumble Sandeep Prabhu, Committee Member
Andrea Marie Mastro, Committee Member
Na Xiong, Committee Member
Connie Jo Rogers, Committee Member
Douglas Cavener, Special Member

Author:

Tang, Xin

Title:

Use of Human induced-pluripotent Stem Cells to Understand Molecular Mechanisms of Autism

Graduate Program:

Biology

Keywords:

Human iPSC
astrocyte
neuron
functional maturation
synapse
KCC2
GABA functional switch
MeCP2
REST
Rett syndrome
Autism

File:

Download Xin_Tang_Dissertation_The_Final_Version_20140409.pdf

Committee Members:

Gong Chen, Dissertation Advisor/Co-Advisor
Douglas Cavener, Committee Chair/Co-Chair
Bernhard Luscher, Committee Member
Melissa Rolls, Committee Member
Yingwei Mao, Committee Member

Author:

Wang, Rong

Title:

PERK eIF2alpha kinase regulates cell proliferation, insulin synthesis and secretion in pancreatic beta cells

Graduate Program:

Genetics

Keywords:

PERK eIF2alpha kinase
Ca2+ dynamics
insulin secretion
insulin biosynthesis
diabetes
ER stress
beta cell proliferation

File:

Download Rong_Wang_Thesis_Dissertation.pdf

Committee Members:

Douglas Cavener, Dissertation Advisor/Co-Advisor
Zhi Chun Lai, Committee Chair/Co-Chair
Richard W Ordway, Committee Member
Gong Chen, Committee Member
Melissa Rolls, Committee Member

Author:

Liu, Jinling

Title:

Genetic analyses of the cilia-dependent hedgehog signal transduction in the mouse

Graduate Program:

Biology

Keywords:

hedgehog
spinal cord patterning
Gli
Sufu
cilia

File:

Download Jinling_Liu_Dissertation_Dec_2_Final.pdf

Committee Members:

Aimin Liu, Dissertation Advisor/Co-Advisor
Zhi Chun Lai, Committee Chair/Co-Chair
Douglas Cavener, Committee Member
Robert Paulson, Committee Member

Author:

Ren, Zhen

Title:

Homeostatic control of glutamate receptor expression by GABAergic deficits and ketamine

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Major depressive disorder (MDD)
ketamine
glutamate receptors
GABAA receptors
homeostatic adaptation

File:

Download 1-Thesis__Zhen_Ren_final.pdf

Committee Members:

Bernhard Luscher, Dissertation Advisor/Co-Advisor
Bernhard Luscher, Committee Chair/Co-Chair
Melissa Rolls, Committee Member
Douglas Cavener, Committee Member
Timothy J Jegla, Committee Member
Pamela Hankey Giblin, Committee Member

Author:

Chen, Li

Title:

Investigation of the molecular basis underlying a multi-step model of axon injury responses

Graduate Program:

Cell and Developmental Biology

Keywords:

axon regeneration
neuroprotection
microtubules
gamma-tubulin
Nmnat
DLK
JNK
fos
caspases
mitochondria

File:

Download ChenDissertationJuly15.pdf

Committee Members:

Melissa Rolls, Dissertation Advisor/Co-Advisor
William O Hancock, Committee Member
Richard W Ordway, Committee Member
Douglas Cavener, Committee Member
Zhi Chun Lai, Committee Member

Author:

Zhu, Siying

Title:

PERK REGULATES CALCIUM DYNAMICS IN COGNITION AND NEURODEGENERATIVE DISEASE

Graduate Program:

Cell and Developmental Biology

Keywords:

PERK
calcium dynamics
working memory
Alzheimer's disease

File:

Download Siying_Zhu_dissertation_2016.pdf

Committee Members:

Douglas Cavener, Dissertation Advisor/Co-Advisor

Author:

Chen, Xiangyun

Title:

Novel Self-assemble nanoparticles to inhibit cancer growth -effects on ER stress, autophagy, and multidrug resistance by a small molecule

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Nanomedicine
Multi-drug resistance
cancer

File:

Download XAC-Thesis-20151209-2.pdf

Committee Members:

Yanming Wang, Dissertation Advisor/Co-Advisor
Douglas Cavener, Committee Chair/Co-Chair
Zhi Chun Lai, Committee Member
Lu Bai, Committee Member
Gavin Peter Robertson, Special Member

Author:

Owusu, Sarah A

Title:

Vitamin A Supplementation: Its Effects on Ontogeny, Lung Development, and Neonatal Lung Injury

Graduate Program:

Physiology

Keywords:

Vitamin A
Retinoic Acid
Neonate
Lung
Ontogeny
VARA
Supplementation
Liver
Kidney

File:

Download Sarah_Owusu_Dissertation_2015_Final.pdf

Committee Members:

A Catharine Ross, Dissertation Advisor/Co-Advisor
Wendy Hanna Rose, Committee Member
Douglas Cavener, Committee Member
Michael Thomas Green, Committee Member

Author:

Lewis, Carrie Rebekah

Title:

THE REGULATION OF ER CHAPERONES AND PROINSULIN PROTEOSTASIS BY PERK EIF2ALPHA KINASE

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

proinsulin
ER chaperones
PERK
EIF2AK3

File:

Download CL_Thesis_Dissertation_FINAL_edited_with_corrections_7-14-16.pdf

Committee Members:

Douglas Cavener, Dissertation Advisor/Co-Advisor
Melissa Rolls, Committee Chair/Co-Chair
Zhi-Chun Lai, Committee Member
Douglas Cavener, Committee Member
Yanming Wang, Outside Member

Author:

sun, jinquan

Title:

A NOVEL SMALL MOLECULE DNA INTERCALATOR PZ1225 IN CANCER CELL APOPTOSIS AND A HISTONE MODIFIER PAD4 IN MACROPHAGE EXTRACELLULAR TRAP FORMATION

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

DNA damage
DNA intercalator
small molecule
MAPK
mTOR
apoptosis
macrophage
extracellular traps
PAD4
citrullination
stroke

File:

Download Graduation_Thesis-Jinquan-20161201.pdf

Committee Members:

Yanming Wang, Dissertation Advisor/Co-Advisor
Zhi-Chun Lai, Committee Chair/Co-Chair
Douglas Cavener, Committee Member
Lu Bai, Committee Member
Robert Paulson, Outside Member

Author:

Cai, Hongchen

Title:

Genetic Analysis Reveals Dual Roles of Speckle-type Poz Protein in Hedgehog Signaling And Mouse Development

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Ubiquitination
Gli3
Skeletal development
osteoporosis
spinal cord patterning

File:

Download Dissertation_HongchenCai_Final.pdf

Committee Members:

Aimin Liu, Dissertation Advisor/Co-Advisor
Aimin Liu, Committee Chair/Co-Chair
Douglas Cavener, Committee Member
Yingwei Mao, Committee Member
Andrea Mastro, Outside Member

Author:

Matsui, Yurika

Title:

THE FUNCTION AND REGULATION OF A TRANSCRIPTIONAL CO-ACTIVATOR YAP IN GROWTH CONTROL AND TISSUE HOMEOSTASIS

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Hippo pathway
Yes-associated protein (YAP)
cell proliferation
apoptosis
isoform
pancreatic beta-cell
large tumor suppressor kinase 1 (LATS1)

File:

Download PhDdissertation_YurikaMatsui.pdf

Committee Members:

Zhi-Chun Lai, Dissertation Advisor/Co-Advisor
Douglas Cavener, Committee Chair/Co-Chair
Melissa Rolls, Committee Member
Michael Axtell, Committee Member
Lorraine C Santy, Outside Member

Author:

Lohay, George Martin

Title:

ELEPHANTS WITHOUT BORDERS: HISTORICAL AND CONTEMPORARY GENETIC CONNECTIVITY IN TANZANIA

Graduate Program:

Biology

Keywords:

African Savanna elephants
Population structure
genetic connectivity
corridors
fecal-centric
microsatellite markers
simple sequence repeats (SSRs)
mitochondrial DNA (mtDNA)
habitat loss
habitat fragmentation
wildlife corridors
age and sex structure
Amelogenin gene (AMELX/Y)

File:

Download Lohay_Dissertation_Final.pdf

Committee Members:

Douglas Cavener, Dissertation Advisor/Co-Advisor
Stephen Wade Schaeffer, Committee Chair/Co-Chair
Katriona Shea, Committee Member
George H Perry, Committee Member
John Edward Carlson, Outside Member
Anna Bond Estes, Special Member

Author:

Wang, Yue

Title:

MECHANISTIC STUDY OF ALZHEIMER’S DISEASE AND NEUROD1-MEDIATED IN VIVO CELL CONVERSION

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

Alzheimer's disease
NeuroD1
Cell conversion
Beneficial effect
GAD67
Haploinsufficiency
Small molecule cocktail
Therapy
In vivo

File:

No files available due to restrictions.

Committee Members:

Gong Chen, Dissertation Advisor/Co-Advisor
Douglas Cavener, Committee Chair/Co-Chair
Bernhard Luscher, Committee Member
Kevin Douglas Alloway, Committee Member
Yingwei Mao, Outside Member

Author:

Hu, Jingjie

Title:

Co-opting regulation bypass repair (CRBR) as gene editing strategy in mouse and human pancreatic beta cells

Graduate Program:

Molecular, Cellular and Integrative Biosciences

Keywords:

CRISPR/Cas9
gene editing
CRBR
monogenic disease
rare disease
Wolcott-Rallison syndrome
PERK(EIF2AK3)
Insulin
diabetes

File:

Download J_Hu_Dissertation_Final_3-24-2021.pdf

Committee Members:

Douglas Cavener, Dissertation Advisor/Co-Advisor
Douglas Cavener, Committee Chair/Co-Chair
Zhi-Chun Lai, Committee Member
Yingwei Mao, Committee Member
Melissa Rolls, Outside Member
Timothy J Jegla, Committee Member
Melissa Rolls, Program Head/Chair

Author:

Son, Jeongin

Title:

Role of the Endoplasmic Reticulum Stress Sensor IRE1 alpha in Ultraviolet B Radiation-Induced Damage Response

Graduate Program:

Molecular, Cellular, and Integrative Biosciences (PHD)

Keywords:

unfolded protein response
UPR
ER stress
IRE1α
Calcium homeostasis
CIB1
UVB
Apoptosis
DNA Damage Repair
ROS
NRF2
Oxidative stress
Inflammation
Angiogenesis

File:

Download Jeongin_Son-Dissertation__Summer_2021_.pdf

Committee Members:

Douglas Cavener, Major Field Member
Adam Glick, Chair & Dissertation Advisor
Girish Kirimanjeswara, Major Field Member
Daniel Hayes, Outside Unit & Field Member
Kumble Prabhu, Major Field Member
Melissa Rolls, Program Head/Chair