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Start Over Year 2022 Committee Member Ralph Keil

1. Using CRISPR Screens to Identify Genetic Vulnerabilities to Cancer Treatment

open_access
Open Access
Author:
Schleicher, Emily
Title:
Using CRISPR Screens to Identify Genetic Vulnerabilities to Cancer Treatment
Graduate Program:
Biomedical Sciences (PHD)
Keywords:
CRISPR
CRISPR Screen
ATM inhibitors
ATR inhibitors
PARP10
Resistance
Sensitivity
CRISPR Knockout
CRISPR Activation
File:
Download EmilySchleicher_FINAL.pdf
Committee Members:
Hong-Gang Wang, Major Field Member
James Broach, Major Field Member
George Moldovan, Chair & Dissertation Advisor
Ralph Keil, Program Head/Chair
David Degraff, Outside Unit & Field Member
Katherine Aird, Special Member

2. Role of Surfactant Protein A and its Receptor SP-R210 in Influenza Responses in Macrophages

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Restricted (Penn State Only)
Author:
Yau, Eric
Title:
Role of Surfactant Protein A and its Receptor SP-R210 in Influenza Responses in Macrophages
Graduate Program:
Biomedical Sciences (PHD)
Keywords:
Surfactant Protein
SP-A
Macrophages
Alveolar Macrophages
Influenza
IAV
Trafficking
Pulmonary Immunity
Pulmonary Inflammation
Surfactant Protein
SP-A
Alveolar Macrophage
Macrophage
AM
Influenza
Influenza A
IAV
Pulmonary Immunity
Pulmonary Inflammation
Trafficking
Virus Trafficking
IAV Trafficking
IAV Endocytosis
Surfactant Protein A
File:
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Committee Members:
Jong Yun, Outside Unit & Field Member
Nicholas Buchkovich, Major Field Member
John Wills, Major Field Member
Zissis Chroneos, Chair & Dissertation Advisor
Ralph Keil, Program Head/Chair

3. The Role Of Regulated In Development and DNA Damage Response 1 (REDD1) in Diabetes-Induced Retinal Pathology and Visual Dysfunction

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Restricted (Penn State Only)
Author:
Miller, William
Title:
The Role Of Regulated In Development and DNA Damage Response 1 (REDD1) in Diabetes-Induced Retinal Pathology and Visual Dysfunction
Graduate Program:
Biomedical Sciences (PHD)
Keywords:
antioxidants
diabetes
oxidative stress
retina
vision
glycogen glycogen synthase kinase 3 (GSK-3)
hyperglycemia
nuclear factor 2 (erythroid-derived 2-like factor) (NFE2L2) (Nrf2)
oxidative stress; post-translational modification (PTM)
reactive oxygen species (ROS)
retinopathy
chaperone mediated autophagy (CMA)
File:
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Committee Members:
Alistair Barber, Outside Unit & Field Member
Jeffrey Sundstrom, Major Field Member
Scot Kimball, Major Field Member
David Waning, Major Field Member
Michael Dennis, Chair & Dissertation Advisor
Ralph Keil, Program Head/Chair

4. Pathologic Substrates of Quantitative Magnetic Resonance Imaging in Parkinsonisms

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Restricted (Penn State Only)
Author:
Wang, Ernest Weider
Title:
Pathologic Substrates of Quantitative Magnetic Resonance Imaging in Parkinsonisms
Graduate Program:
Biomedical Sciences (PHD)
Keywords:
MRI
parkinsonisms
pathology
neuropathology
gene-environment
pesticides
paraquat
HFE
susceptibility MRI
DTI
substantia nigra
iron
Parkinson's disease
progressive supranuclear palsy
multiple system atrophy
corticobasal degeneration
dopamine
movement disorders
neurology
brain
File:
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Committee Members:
Xuemei Huang, Chair & Dissertation Advisor
Guangwei Du, Major Field Member
Gary Perdew, Outside Unit & Field Member
James Connor, Major Field Member
Matthew Coates, Special Member
Ralph Keil, Program Head/Chair

5. Novel Therapeutic Thermogels as Local Controlled-Release Drug Delivery Systems for Peripheral Nerve Injury

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Restricted
Author:
Manto, Kristen
Title:
Novel Therapeutic Thermogels as Local Controlled-Release Drug Delivery Systems for Peripheral Nerve Injury
Graduate Program:
Biomedical Sciences (PHD)
Keywords:
thermogel
hydrogel
PLGA
PEG
4-AP
EPO
peripheral nerve
nerve regeneration
controlled-release
local drug delivery
myelin
axonal continuity
nerve injury
File:

No files available due to restrictions.

Committee Members:
Marc Kaufman, Major Field Member
James Connor, Co-Chair of Committee
David Waning, Outside Unit & Field Member
Kimberly S Harbaugh, Special Member
John Elfar, Co-Chair & Dissertation Advisor
Ralph Keil, Program Head/Chair

6. REVEALING THE ORAI-STIM BINDING INTERFACE THROUGH THE USE OF NOVEL PEPTIDES

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Restricted (Penn State Only)
Author:
Baraniak, James
Title:
REVEALING THE ORAI-STIM BINDING INTERFACE THROUGH THE USE OF NOVEL PEPTIDES
Graduate Program:
Biomedical Sciences (PHD)
Keywords:
calcium
store-operated calcium entry
soce
calcium homeostasis
STIM
Orai
Calcium channels
M4x peptide
peptide modulation
Orai binding interface
SOAR
stormorken
signal transduction
NFAT
pan-specific inhibition
stim-orai interacting interface
File:
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Committee Members:
Salvatore Stella, Outside Unit Member
Thomas Spratt, Outside Field Member
Christopher Yengo, Major Field Member
Donald Gill, Chair & Dissertation Advisor
Ralph Keil, Program Head/Chair

7. The Role of Polyomavirus Capsid Mutations in Antibody Evasion and Virulence

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Restricted (Penn State Only)
Author:
Lauver, Matthew
Title:
The Role of Polyomavirus Capsid Mutations in Antibody Evasion and Virulence
Graduate Program:
Biomedical Sciences (PHD)
Keywords:
Polyomavirus
Antibody Evasion
Virus Capsid Mutations
Viral Pathogenesis
T cell Deficiency
File:
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Committee Members:
Nicholas Buchkovich, Major Field Member
Aron Lukacher, Chair & Dissertation Advisor
Todd Schell, Major Field Member
Zissis Chroneos, Outside Unit & Field Member
Ralph Keil, Program Head/Chair

8. PARP14 regulates cyclin D1 expression to promote cell cycle progression

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Restricted (Penn State Only)
Author:
O'Connor, Michael
Title:
PARP14 regulates cyclin D1 expression to promote cell cycle progression
Graduate Program:
Biomedical Sciences (PHD)
Keywords:
cell cycle
cyclin D1
CDK4/6 inhibitors
CRISPR
PARP14
breast cancer
File:
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Committee Members:
Thomas Spratt, Committee Member & Major Field Represnt
James Broach, Committee Member & Major Field Represnt
Ralph Keil, Committee Member & Major Field Represnt
Lisa Shantz, Committee Member & Related Areas Repres
George Moldovan, Chair & Major Field Represnt
Ralph Keil, Program Head/Chair

9. Effects of Vertical Sleeve Gastrectomy on Taste Preferences and Underlying Neural Signaling in an Obese Rat Model of Spinal Cord Injury

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Restricted (Penn State Only)
Author:
Tang, Tiffany
Title:
Effects of Vertical Sleeve Gastrectomy on Taste Preferences and Underlying Neural Signaling in an Obese Rat Model of Spinal Cord Injury
Graduate Program:
Biomedical Sciences (MS)
Keywords:
spinal cord injury
vertical sleeve gastrectomy
neural mechanisms
obesity
taste preference
File:
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Committee Members:
Andras Hajnal, Thesis Advisor/Co-Advisor
Yuval Silberman, Committee Member
Ralph Keil, Program Head/Chair
Ziaur Rahman, Committee Member

10. Effects of schweinfurthin analogue 5’-methylschweinfurthin G in multiple myeloma cell lines

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Restricted (Penn State Only)
Author:
Manfredi, Barbara
Title:
Effects of schweinfurthin analogue 5’-methylschweinfurthin G in multiple myeloma cell lines
Graduate Program:
Biomedical Sciences (PHD)
Keywords:
multiple myeloma
schweinfurthin G
5’-methylschweinfurthin G
cytotoxicity
natural product
MIP-1α
Golgi secretion
AKT
human-derived cell lines
File:
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Committee Members:
Elizabeth Proctor, Outside Field Member
Kent Vrana, Major Field Member
Raymond Hohl, Chair & Dissertation Advisor
Barbara Miller, Outside Unit Member
Jeffrey Neighbors, Major Field Member
Ralph Keil, Program Head/Chair