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Author:

Yoast, Ryan

Title:

The Coordinated Functions of STIM1/2, ORAI1/2/3, and MCU Underlie the Diversity of Physiological Ca2+ Signaling

Graduate Program:

Biomedical Sciences (PHD)

Keywords:

STIM
ORAI
MCU
Calcium Signaling
Calcium Oscillations
SOCE
CRAC channels
NFAT
Mitochondrial Calcium
IP3R
CRISPR/Cas9

File:

Download Yoast_Doctoral_Thesis_2021_Final_6-12-21.pdf

Committee Members:

David Degraff, Outside Field Member
Mohamed Trebak, Chair & Dissertation Advisor
Todd Schell, Outside Unit Member
Christopher Yengo, Major Field Member
Ralph Keil, Program Head/Chair

Author:

Schleicher, Emily

Title:

Using CRISPR Screens to Identify Genetic Vulnerabilities to Cancer Treatment

Graduate Program:

Biomedical Sciences (PHD)

Keywords:

CRISPR
CRISPR Screen
ATM inhibitors
ATR inhibitors
PARP10
Resistance
Sensitivity
CRISPR Knockout
CRISPR Activation

File:

Download EmilySchleicher_FINAL.pdf

Committee Members:

Hong-Gang Wang, Major Field Member
James Broach, Major Field Member
George Moldovan, Chair & Dissertation Advisor
Ralph Keil, Program Head/Chair
David Degraff, Outside Unit & Field Member
Katherine Aird, Special Member

Author:

Emrich, Scott

Title:

Insights into the Diversity of Calcium Signaling in B Lymphocytes

Graduate Program:

Biomedical Sciences (PHD)

Keywords:

Calcium signaling
Immunity
B lymphocyte
Store-operated Ca2+ entry

File:

Download Emrich_Thesis_2021_Final.pdf

Committee Members:

Neil Christensen, Major Field Member
Salvatore Stella, Major Field Member
Laura Carrel, Outside Unit & Field Member
Mohamed Trebak, Chair & Dissertation Advisor
Donald Gill, Major Field Member
Ralph Keil, Program Head/Chair

Author:

Yau, Eric

Title:

Role of Surfactant Protein A and its Receptor SP-R210 in Influenza Responses in Macrophages

Graduate Program:

Biomedical Sciences (PHD)

Keywords:

Surfactant Protein
SP-A
Macrophages
Alveolar Macrophages
Influenza
IAV
Trafficking
Pulmonary Immunity
Pulmonary Inflammation
Surfactant Protein
SP-A
Alveolar Macrophage
Macrophage
AM
Influenza
Influenza A
IAV
Pulmonary Immunity
Pulmonary Inflammation
Trafficking
Virus Trafficking
IAV Trafficking
IAV Endocytosis
Surfactant Protein A

File:

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Committee Members:

Jong Yun, Outside Unit & Field Member
Nicholas Buchkovich, Major Field Member
John Wills, Major Field Member
Zissis Chroneos, Chair & Dissertation Advisor
Ralph Keil, Program Head/Chair

Author:

Miller, William

Title:

The Role Of Regulated In Development and DNA Damage Response 1 (REDD1) in Diabetes-Induced Retinal Pathology and Visual Dysfunction

Graduate Program:

Biomedical Sciences (PHD)

Keywords:

antioxidants
diabetes
oxidative stress
retina
vision
glycogen glycogen synthase kinase 3 (GSK-3)
hyperglycemia
nuclear factor 2 (erythroid-derived 2-like factor) (NFE2L2) (Nrf2)
oxidative stress; post-translational modification (PTM)
reactive oxygen species (ROS)
retinopathy
chaperone mediated autophagy (CMA)

File:

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Committee Members:

Alistair Barber, Outside Unit & Field Member
Jeffrey Sundstrom, Major Field Member
Scot Kimball, Major Field Member
David Waning, Major Field Member
Michael Dennis, Chair & Dissertation Advisor
Ralph Keil, Program Head/Chair

Author:

Wang, Ernest Weider

Title:

Pathologic Substrates of Quantitative Magnetic Resonance Imaging in Parkinsonisms

Graduate Program:

Biomedical Sciences (PHD)

Keywords:

MRI
parkinsonisms
pathology
neuropathology
gene-environment
pesticides
paraquat
HFE
susceptibility MRI
DTI
substantia nigra
iron
Parkinson's disease
progressive supranuclear palsy
multiple system atrophy
corticobasal degeneration
dopamine
movement disorders
neurology
brain

File:

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Committee Members:

Xuemei Huang, Chair & Dissertation Advisor
Guangwei Du, Major Field Member
Gary Perdew, Outside Unit & Field Member
James Connor, Major Field Member
Matthew Coates, Special Member
Ralph Keil, Program Head/Chair

Author:

Manto, Kristen

Title:

Novel Therapeutic Thermogels as Local Controlled-Release Drug Delivery Systems for Peripheral Nerve Injury

Graduate Program:

Biomedical Sciences (PHD)

Keywords:

thermogel
hydrogel
PLGA
PEG
4-AP
EPO
peripheral nerve
nerve regeneration
controlled-release
local drug delivery
myelin
axonal continuity
nerve injury

File:

No files available due to restrictions.

Committee Members:

Marc Kaufman, Major Field Member
James Connor, Co-Chair of Committee
David Waning, Outside Unit & Field Member
Kimberly S Harbaugh, Special Member
John Elfar, Co-Chair & Dissertation Advisor
Ralph Keil, Program Head/Chair

Author:

Baraniak, James

Title:

REVEALING THE ORAI-STIM BINDING INTERFACE THROUGH THE USE OF NOVEL PEPTIDES

Graduate Program:

Biomedical Sciences (PHD)

Keywords:

calcium
store-operated calcium entry
soce
calcium homeostasis
STIM
Orai
Calcium channels
M4x peptide
peptide modulation
Orai binding interface
SOAR
stormorken
signal transduction
NFAT
pan-specific inhibition
stim-orai interacting interface

File:

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Committee Members:

Salvatore Stella, Outside Unit Member
Thomas Spratt, Outside Field Member
Christopher Yengo, Major Field Member
Donald Gill, Chair & Dissertation Advisor
Ralph Keil, Program Head/Chair

Author:

Lauver, Matthew

Title:

The Role of Polyomavirus Capsid Mutations in Antibody Evasion and Virulence

Graduate Program:

Biomedical Sciences (PHD)

Keywords:

Polyomavirus
Antibody Evasion
Virus Capsid Mutations
Viral Pathogenesis
T cell Deficiency

File:

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Committee Members:

Nicholas Buchkovich, Major Field Member
Aron Lukacher, Chair & Dissertation Advisor
Todd Schell, Major Field Member
Zissis Chroneos, Outside Unit & Field Member
Ralph Keil, Program Head/Chair

Author:

O'Connor, Michael

Title:

PARP14 regulates cyclin D1 expression to promote cell cycle progression

Graduate Program:

Biomedical Sciences (PHD)

Keywords:

cell cycle
cyclin D1
CDK4/6 inhibitors
CRISPR
PARP14
breast cancer

File:

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Committee Members:

Thomas Spratt, Committee Member & Major Field Represnt
James Broach, Committee Member & Major Field Represnt
Ralph Keil, Committee Member & Major Field Represnt
Lisa Shantz, Committee Member & Related Areas Repres
George Moldovan, Chair & Major Field Represnt
Ralph Keil, Program Head/Chair