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Open Access

Author:: Sarkar, Debolina
Title:: Integrated Modeling of Phototrophic Metabolism Leveraging Multi-Omics Datasets
Graduate Program:: Chemical Engineering (PHD)
Keywords:: flux balance analysis
metabolic engineering
SNPs
poplar
arabidopsis
cyanobacteria
constraints based analysis
optimization
File:: Download Debolina_Sarkar_thesis_040522.pdf
Committee Members:: Andrew Zydney, Major Field Member
Phillip Savage, Major Field Member
Costas Maranas, Chair & Dissertation Advisor
Seong H. Kim, Professor in Charge/Director of Graduate Studies
Sally Mackenzie, Outside Unit & Field Member

Open Access

Author:: Foster, Charles
Title:: Leveraging the Kinetics of Metabolism and Microbial Growth for Metabolic Engineering and Scientific Discovery in Clostridia
Graduate Program:: Chemical Engineering (PHD)
Keywords:: Clostridia
Clostridium thermocellum
Clostridium acetobutylicum
Clostridium ljungdahlii
kinetic modeling
metabolism
genome-scale reconstruction
microbial consortia
metabolic engineering
bioprocess engineering
File:: Download Thesis_CF_011522.pdf
Committee Members:: Andrew Zydney, Major Field Member
Joseph Cotruvo, Outside Unit & Field Member
Costas Maranas, Chair & Dissertation Advisor
Seong Han Kim, Professor in Charge/Director of Graduate Studies
Ali Borhan, Major Field Member

Restricted (Penn State Only)

Author:: Nejatishahidein, Negin
Title:: DEPTH FILTERS IN BIOPROCESSING: PERFORMANCE AND SCALE-UP
Graduate Program:: Chemical Engineering (PHD)
Keywords:: CFD
clarification
depth filtration
flow distribution
lenticular stack
scale‐up
cell culture fluid
host cell proteins
protein binding
monoclonal antibodies
flow structure
File:: Login to Download
Committee Members:: Andrew Zydney, Chair & Dissertation Advisor
William Hancock, Outside Unit & Field Member
Ali Borhan, Major Field Member
Stephanie Velegol, Major Field Member
Seong H. Kim, Professor in Charge/Director of Graduate Studies

Open Access

Author:: Jabra, Mario
Title:: Development of Ultrafiltration and Diafiltration Processes for Batch and Continuous Formulation of Monoclonal Antibodies
Graduate Program:: Chemical Engineering (PHD)
Keywords:: Ultrafiltration
Diafiltration
Continuous
Multistage countercurrent
pH shift
Excipient Shift
Bioprocessing
membrane filtration
Single Pass tangential flow filtration
SPTFF
Mechanistic Modelling
SPTFF optimization
Buffer Exchange
Countercurrent Dialysis
Continuous Ultrafiltration
Continuous Diafiltration
Membrane Processing
Monoclonal Antibody
IgG
Therapeutic Protein
Formulation
File:: Download Final_Thesis_by_Mario_Jabra.pdf
Committee Members:: Andrew Zydney, Chair & Dissertation Advisor
William Hancock, Outside Unit & Field Member
Wayne Curtis, Major Field Member
Darrell Velegol, Major Field Member
Seong H. Kim, Professor in Charge/Director of Graduate Studies

Open Access

Author:: Taylor, Neil
Title:: Sterile Filtration Of Large Particle Therapeutics - New Insights Using A Live Attenuated Viral Vaccine And A Model Nanoparticle Suspension
Graduate Program:: Chemical Engineering (PHD)
Keywords:: Sterile Filtration
Live Attenuated Viral Vaccine
Nanoparticles
Pore Size Distribution
Fouling
Prefiltration
File:: Download Neil_Taylor-thesis-final.pdf
Committee Members:: Andrew Zydney, Chair & Dissertation Advisor
William Hancock, Outside Unit & Field Member
Themis Matsoukas, Major Field Member
Stephanie Velegol, Major Field Member
Seong H. Kim, Professor in Charge/Director of Graduate Studies

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